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Selective targeting agents for mitochondria

  • US 9,006,186 B2
  • Filed: 10/21/2013
  • Issued: 04/14/2015
  • Est. Priority Date: 01/06/2006
  • Status: Active Grant
First Claim
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1. A method for delivering a moiety to mitochondria of a patient comprising administering to a patient a mitochondria-targeting compound comprising a membrane-active fragment of gramicidin S or an E-alkene isostere thereof conjugated to a moiety, wherein the gramicidin S fragment or E-alkene isostere thereof has the sequence Leu-DPhe-Pro-Val-Orn, and wherein the moiety is a reactive-oxygen species (ROS) scavenger.

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