Methods and systems for lowering blood pressure through reduction of ventricle filling
First Claim
1. A system for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:
- a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber; and
at least one controller configured to execute the delivery of one or more stimulation patterns of stimulation pulses to at least one cardiac chamber, wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting, at least one of the first stimulation setting and the second stimulation setting being configured to reduce or prevent atrial kick, thereby reducing the ventricular filling volume from the pretreatment ventricular filling volume.
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Accused Products
Abstract
Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient'"'"'s heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient'"'"'s heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.
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Citations
33 Claims
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1. A system for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:
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a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber; and at least one controller configured to execute the delivery of one or more stimulation patterns of stimulation pulses to at least one cardiac chamber, wherein at least one of the stimulation pulses has a first stimulation setting and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting, at least one of the first stimulation setting and the second stimulation setting being configured to reduce or prevent atrial kick, thereby reducing the ventricular filling volume from the pretreatment ventricular filling volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A system for reducing ventricular filling volume of a patient having a pretreatment ventricular filling volume, comprising:
- a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber; and
at least one controller configured to execute the delivery of one or more stimulation patterns of stimulation pulses to at least one cardiac chamber, wherein at least one of the stimulation pulses includes a setting configured to cause a ventricular excitation to commence between about 0 ms and about 70 ms after the onset of atrial excitation, configured to reduce or prevent atrial kick in at least one ventricle, thereby reducing the ventricular filling volume from the pretreatment ventricular filling volume.
- a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber; and
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32. A system for reducing ventricular filling volume in a patient having a pretreatment ventricular filling volume, comprising:
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a stimulation circuit configured to deliver a stimulation pulse to at least one cardiac chamber; at least one controller configured to execute the delivery of one or more stimulation patterns of stimulation pulses to at least one cardiac chamber for a time interval lasting 10 minutes or longer, wherein at least one of the stimulation pulses has a first stimulation setting configured to reduce or prevent atrial kick in at least one ventricle for at least 5 minutes of the time interval and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting, thereby reducing the ventricular filling volume from the pretreatment ventricular filling volume.
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33. A method of reducing ventricular filling in a patient having a pretreatment ventricular filling volume, comprising:
delivering one or more stimulation patterns of stimulation pulses to at least one cardiac chamber for a time interval lasting 10 minutes or longer, wherein at least one of the stimulation pulses has a first stimulation setting configured to reduce or prevent atrial kick in at least one ventricle for at least 5 minutes of the time interval and at least one of the stimulation pulses has a second stimulation setting different from the first stimulation setting, thereby reducing the ventricular filling volume from the pretreatment ventricular filling volume.
Specification