Retinal prosthesis

• US 9,008,785 B2
• Filed: 12/30/2011
• Issued: 04/14/2015
• Est. Priority Date: 12/30/2010
• Status: Active Grant

• Current Assignee: STMicroelectronics SRL (STMicroelectronics NV)
• Original Assignee: STMicroelectronics SRL (STMicroelectronics NV)
• Inventors: Pagani, Alberto
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin
• Application Number:
  US13/977,121
• Publication Number:
  US 20130282119A1
• Time in Patent Office: 1,201 Days
• Field of Search: 607/53, 607/54
• US Class Current: 607/54
• CPC Class Codes: A61F 2/14 Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
• CPC Class Codes: A61F 2/148 Implantation instruments specially adapted therefor
• CPC Class Codes: A61F 2250/0002 for data transfer
• CPC Class Codes: A61F 9/08 Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

A retinal prosthesis including an electronic stimulation unit housed inside an eye and including: a plurality of electrodes that contact a portion of a retina of the eye; an electronic control circuit, which is electrically connected to the electrodes and supplies to the electrodes electrical stimulation signals designed to stimulate the portion of retina; and a local antenna connected to the electronic control circuit. The retinal prosthesis further includes an electromagnetic expansion housed inside the eye and formed by a first expansion antenna and a second expansion antenna electrically connected together, the first expansion antenna being magnetically or electromagnetically coupled to an external antenna, the second expansion antenna being magnetically or electromagnetically couple to the local antenna, the electromagnetic expansion moreover receiving an electromagnetic supply signal transmitted by the external antenna and generating a corresponding replica signal.

Claims

1. A retinal prosthesis comprising:

an electronic stimulation unit, which is configured to be housed inside an eye, the electronic stimulation unit comprising;

a plurality of electrodes, configured to contact a portion of a retina of the eye;

an electronic control circuit electrically connected to said electrodes and configured to supply to the electrodes electrical stimulation signals designed to stimulate said portion of retina; and

a local antenna packaged in the electronic stimulation unit and connected to the electronic control circuit; and

an electromagnetic expansion, which is configured to be housed inside the eye, the electromagnetic expansion comprising;

a first expansion antenna; and

a second expansion antenna electrically coupled with the first expansion antenna, wherein the first expansion antenna is coupleable magnetically or electromagnetically to an external antenna, and the second expansion antenna is coupleable magnetically or electromagnetically to said local antenna, and

wherein the electromagnetic expansion is further configured to receive an electromagnetic supply signal transmitted by said external antenna and generate a corresponding replica signal for reception in the local antenna.

2. The retinal prosthesis according to claim 1, wherein the electronic control circuit comprises a supply stage connected to the local antenna and configured to generate, following upon reception of the replica signal, a converted signal to supply the electronic control circuit.

3. The retinal prosthesis according to claim 2, wherein said supply stage comprises an AC/DC converter.

4. The retinal prosthesis according to claim 1, wherein the electromagnetic expansion is configured to resonate in response to reception of the electromagnetic supply signal.

5. The retinal prosthesis according to claim 1, wherein the electromagnetic expansion further comprises an electrical network including at least one of a reactive element and a matching network configured to match the impedances of the first and second expansion antennas.

6. The retinal prosthesis according to claim 1, wherein the electromagnetic expansion comprises at least one arm hinged to the second expansion antenna about a first axis of rotation.

7. The retinal prosthesis according to claim 6, wherein the electromagnetic expansion is elastically displaceable between a resting state, where the arm is straight, and an operative state, where the arm substantially assumes, at least locally, a radius of curvature of an inner wall of the eye.

8. The retinal prosthesis according to claim 6, wherein the arm is hinged to the first expansion antenna about a second axis of rotation, and the electromagnetic expansion is elastically displaceable between a resting state, in which the first and second axes of rotation are distinct, and an operative state, in which the first and second axes of rotation coincide.

9. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit comprises a dielectric region, a first connection region housing first conductive connection lines, and a first body of semiconductor material, the first body being arranged between, and in direct contact with, the dielectric region and the first connection region, the electronic control circuit being formed at least in part inside the first body;

and wherein the local antenna is housed inside the dielectric region and is connected to the electronic control circuit by the first conductive connection lines and by a pair of conductive elements that extend through the first body.

10. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit comprises a first connection region housing first conductive connection lines, and a first body of semiconductor material contiguous to the first connection region, the electronic control circuit being formed at least in part inside the first body;

and wherein the local antenna is housed inside the first connection region and is connected to the electronic control circuit by the first conductive connection lines.

11. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit comprises a first integrated circuit and a second integrated circuit,

the first integrated circuit comprising a first body of semiconductor material, a first connection region, which is contiguous to the first body and houses first conductive connection lines, and a passivation region, which is contiguous to the first connection region;

the second integrated circuit comprising a second body of semiconductor material and a second connection region, which is contiguous to the second body and houses second conductive connection lines, the first and second integrated circuits being connected by interposition of an insulating region contiguous to the first body and to the second connection region;

the electronic stimulation unit-further comprising a dielectric region contiguous to the passivation region; and

wherein the electronic control circuit comprises a first electronic circuitry, formed at least in part inside the first body, and a second electronic circuitry, formed at least in part inside the second body, the first and second electronic circuitries being electrically connected by means of at least one metal via, which extends through the first body and the insulating region; and

wherein the local antenna is housed inside the dielectric region and is electrically connected to the first electronic circuitry.

12. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit comprises a first integrated circuit and a second integrated circuit,

the first integrated circuit comprising a first body of semiconductor material, a first connection region contiguous to the first body and housing first conductive connection lines, and a passivation region contiguous to the first connection region;

the second integrated circuit comprising a second body of semiconductor material and a second connection region, which is contiguous to the second body and houses second conductive connection lines, the first and second integrated circuits being connected by interposition of an insulating region, contiguous to the first body and to the second connection region; and

wherein the electronic control circuit comprises a first electronic circuitry, formed at least in part inside the first body, and a second electronic circuitry, formed at least in part inside the second body, the first and second electronic circuitries being electrically connected by means of at least one metal via extending through the first body and the insulating region; and

wherein the local antenna is housed inside the first connection region and is electrically connected to the first electronic circuitry.

13. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit further comprises a layer of polymeric material, the electrodes being formed partially within the layer of polymeric material.

14. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit further comprises a package of insulating material, which encloses the electronic control circuit and the local antenna, the electrodes extending at least in part outside the package.

15. The retinal prosthesis according to claim 1, wherein the electronic stimulation unit comprises a magnet configured for constraining the electronic stimulation unit to the electromagnetic expansion.

16. The retinal prosthesis according to claim 1, comprising an external unit including said external antenna, an external transceiver connected to the external antenna, and an image-acquisition device connected to the external transceiver;

and wherein the electronic control circuit comprises an internal transceiver, connected to the local antenna.

17. The retinal prosthesis according to claim 1, wherein the first and second expansion antennas are spiral antennas, and wherein the electronic stimulation unit is surrounded at least in part by the second expansion antenna.

18. A retinal prosthesis house-able inside an eye, the prosthesis comprising:

an electronic stimulation unit packaged in a single assembly, the electronic stimulation unit comprising;

a plurality of electrodes configured to stimulate the retina of the eye;

an electronic control unit; and

an integral antenna packaged inside the single assembly of the electronic stimulation unit; and

an electromagnetic expansion comprising a first expansion antenna and a second expansion antenna configured to relay signals from an external antenna to the integral antenna of the electronic stimulation unit such that when the electronic stimulation unit requires replacement, the electromagnetic expansion stays in the eye.

19. The retinal prosthesis of claim 18, wherein the electromagnetic expansion comprises at least one arm hinged to the second expansion antenna about a first axis of rotation.

20. The retinal prosthesis of claim 19, wherein the arm is hinged to the first expansion antenna about a second axis of rotation, and the electromagnetic expansion is elastically displaceable between a resting state, in which the first and second axes of rotation are distinct, and an operative state, in which the first and second axes of rotation coincide.