Nasal delivery devices

• US 9,010,325 B2
• Filed: 11/28/2007
• Issued: 04/21/2015
• Est. Priority Date: 11/28/2006
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle, Sheldrake, Colin David, Smith, Simon, Striebig, Rachel, Pidgeon, Andy, St. Quintin, Tom
• Primary Examiner(s): Skorupa, Valerie L
• Assistant Examiner(s): SUL, DOUGLAS YOUNG
• Application Number:
  US12/516,404
• Publication Number:
  US 20100300439A1
• Time in Patent Office: 2,701 Days
• Field of Search: 128/200.14, 128/200.23, 128/203.12, 128/203.15, 128/203.18, 128/203.19, 128/203.21, 128/203.23, 128/207.18, 222/74, 222/153.09, 222/153.11, 222/153.13, 222/153.14, 222/239, 137/614.06, 251/89.5, 251/149.9
• US Class Current: 128/203.18
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0026 Hinged caps
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 15/0043 Non-destructive separation of the package, e.g. peeling
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/1045 Devices for humidifying or heating the inspired gas by using recovered moisture or heat from the expired gas
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 Mouth

Abstract

A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly (3) including a mouthpiece unit (9) which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit (5) which includes a nosepiece and contains a container containing particulate substance.

Claims

1. A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising:

a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, a substance-supply unit which is fluidly connected to the mouthpiece unit and configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance, and an actuation mechanism which is manually actuatable by the subject to open the container;

wherein the substance-supply unit is actuatable to provide particulate substance for delivery to the nasal airway of the subject, and includes an interlock mechanism which adopts a first, locking configuration when a nosepiece unit is not fitted to the body assembly, in which the actuation mechanism is locked, and a second, released configuration when a nosepiece unit is fitted to the body assembly, in which the actuation mechanism is actuatable.

2. The delivery device of claim 1, further comprising:

a replaceable nosepiece unit which includes a nosepiece for fitting to a nostril of a subject, and a container chamber which contains a container containing particulate substance.

3. A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising:

a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, a substance-supply unit which is fluidly connected to the mouthpiece unit and configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance, and an actuation mechanism which is manually actuatable by the subject to open the container;

wherein the substance-supply unit is actuatable to provide particulate substance for delivery to the nasal airway of the subject, and includes an interlock mechanism which adopts a first, locking configuration when a nosepiece unit is not fitted to the body assembly, in which the actuation mechanism is not actuatable, and a second, released configuration when a nosepiece unit is fitted to the body assembly, in which the actuation mechanism is actuatable;

wherein the interlock mechanism comprises an interlock member which is movably disposed between locking and released positions and normally biased to the locking position.

4. A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising:

a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance;

wherein the substance-supply unit is actuatable to provide particulate substance for delivery to the nasal airway of the subject, and includes an interlock mechanism which adopts a first, locking configuration when a nosepiece unit is not fitted to the body assembly, in which the actuation mechanism is not actuatable, and a second, released configuration when a nosepiece unit is fitted to the body assembly, in which the actuation mechanism is actuatable, and a valve unit which is operable between a first, closed configuration in which a fluid communication path with the mouthpiece is closed, and a second, open configuration in which the fluid communication path is open, and the interlock mechanism is configured to lock the valve unit in the closed configuration when the interlock mechanism is in the locking configuration and allow operation of the valve unit when the interlock mechanism is in the released configuration.

5. The delivery device of claim 4, further comprising:

a replaceable nosepiece unit which includes a nosepiece for fitting to a nostril of a subject, and a container chamber which contains a container containing particulate substance.

6. The delivery device of claim 4, wherein the valve unit includes a locking element which is engaged by the interlock mechanism when the interlock mechanism is in the locking configuration to prevent operation of the valve unit.

7. A nasal delivery device for delivering particulate substance to the nasal airway of a subject, the delivery device comprising:

a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance;

wherein the substance-supply unit is actuatable to provide particulate substance for delivery to the nasal airway of the subject, and includes an interlock mechanism which adopts a first, locking configuration when a nosepiece unit is not fitted to the body assembly, in which the actuation mechanism is locked in a locked configuration to prevent operation of the actuation mechanism, and a second, released configuration when a nosepiece unit is fitted to the body assembly, in which the actuation mechanism is actuatable.

8. The delivery device of claim 7, wherein the nosepiece unit includes a release member for releasing the actuation mechanism from the locked configuration on fitting the nosepiece unit to the body assembly.

9. The delivery device of claim 8, wherein the actuation mechanism includes an actuation member which is latched in a locked position in the locked configuration of the actuation mechanism, and the release member of the nosepiece unit is operative to release the latched actuation member on fitting the nosepiece unit to the body assembly.

10. The delivery device of claim 8, wherein the nosepiece unit is fitted to the body assembly in one, fitting sense and removed from the body assembly in the opposite, removal sense, and the release member includes a support element, an engagement element for engaging the actuation mechanism and a frangible connection element which connects the support element to the engagement element, wherein the engagement element presents a substantially rigid structure when the nosepiece unit is fitted in a first instance to the body assembly and is operative to release the actuation mechanism from the locked configuration, and is deformed on removing the nosepiece unit from the body assembly.

11. The delivery device of claim 7, further comprising:

a replaceable nosepiece unit which includes a nosepiece for fitting to a nostril of a subject, and a container chamber which contains a container containing particulate substance.