Capsule camera with variable illumination of the surrounding tissue

• US 9,011,321 B2
• Filed: 06/06/2014
• Issued: 04/21/2015
• Est. Priority Date: 07/24/2006
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Hendriks, Bernardus Hendrikus Wilhelmus, Kuhn, Michael Harald, Zaengel, Thomas, Van Der Vaart, Nijs Cornelis
• Primary Examiner(s): Nguyen, Anhtuan T
• Assistant Examiner(s): CHOU, WILLIAM B
• Application Number:
  US14/298,246
• Publication Number:
  US 20140288368A1
• Time in Patent Office: 319 Days
• Field of Search: 600/109, 600/160, 600/167, 600/173, 600/177, 600/178, 356/665, 356/666
• US Class Current: 600/167
• CPC Class Codes: A61B 1/00087 Tools A61B17/00234 takes precedence
• CPC Class Codes: A61B 1/00165 with light-conductive means, e.g. fibre optics A61B1/07 takes precedence
• CPC Class Codes: A61B 1/00188 with focusing or zooming features
• CPC Class Codes: A61B 1/0019 characterised by variable lenses
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 1/0625 for multiple fixed illumination angles
• CPC Class Codes: A61B 1/0627 for variable illumination angles
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 2018/00482 Digestive system
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61B 2018/00642 with feedback, i.e. closed loop control
• CPC Class Codes: A61B 2018/00904 Automatic detection of target tissue
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61N 2005/0609 Stomach and/or esophagus
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 : for treatment of body cavities
• CPC Class Codes: A61N 5/062 : Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G03B 15/02 : Illuminating scene

Abstract

The invention relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas; a control unit in communication with the image sensor, the at least one light source, and variable lens system, the control unit comprising image storing means, processing means and image transmission means; wherein the control unit correlates stored images received from the image sensor as the capsule travels through the gastrointestinal tract and controls the beam steering means and focusing means of the variable lens system to ensure that the light beams from the at least one light source are directed and focused onto the diseased tissue areas; a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

Claims

1. A method for in vivo imaging of one or more tissue areas of interest within the gastrointestinal tract of an animal or human being comprising:

ingesting a capsule comprising;

an image sensor;

a lens system for focusing images of interest onto the image sensor;

at least one light source for providing illumination to the tissue of the gastrointestinal tract and is optionally capable of providing optical therapeutic treatment to the diseased tissue areas;

a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas;

a control unit in communication with the image sensor, the at least one light source, and variable lens system, the control unit comprising image storing means, processing means and image transmission means;

wherein the control unit correlates stored images received from the image sensor as the capsule travels through the gastrointestinal tract and controls the beam steering means and focusing means of the variable lens system to ensure that the light beams from the at least one light source are directed and focused onto the diseased tissue areas;

a power source for powering the image sensor, the at least one light source and the control unit; and

a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source;

transmitting the image data from the control unit to an external image receiving and viewing unit, and viewing the image data.

2. The method of claim 1, wherein the first and second light sources are each lasers.

3. The method of claim 1, wherein the variable lens system comprises a liquid lens system.

4. The method of claim 1 for in vivo imaging of one or more tissue areas of interest within the gastrointestinal tract of an animal or human being comprising:

ingesting a capsule comprising;

an image sensor;

a lens system for focusing images of interest onto the image sensor;

first and second light sources for providing illumination to the tissue of the gastrointestinal tract;

wherein the second light source is optionally capable of providing optical therapeutic treatment to the diseased tissue areas;

a variable lens system located in front of the first light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the first light source onto the diseased tissue areas;

a control unit in communication with the image sensor, first and second light sources, and variable lens system, the control unit comprising image storing means, processing means and image transmission means;

wherein the control unit correlates stored images received from the image sensor as the capsule travels through the gastrointestinal tract and controls the beam steering means and focusing means of the variable lens system to ensure that the light beams from the first light source are directed and focused onto the diseased tissue areas;

a power source for powering the image sensor, the first and second light sources and the control unit; and

a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the first and second light sources, the variable lens system, the control unit and the power source;

transmitting the image data from the control unit to an external image receiving and viewing unit, and viewing the image data.

5. A method for in vivo treatment of one or more diseased tissue areas of interest within the gastrointestinal tract of an animal or human being comprising:

ingesting into the gastrointestinal tract a fluorescence marking agent that will chemically bind to the diseased tissue areas only and cause the diseased tissue areas to transmit fluorescent light beams when stimulated by a light source;

thereafter ingesting a capsule comprising;

an image sensor;

a lens system for focusing images of interest onto the image sensor;

at least one light source for providing illumination to the tissue of the gastrointestinal tract and is optionally capable of providing optical therapeutic treatment to the diseased tissue areas;

a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas;

a control unit in communication with the image sensor, the at least one light source, and variable lens system, the control unit comprising image storing means, processing means and image transmission means;

wherein the control unit correlates stored images received from the image sensor as the capsule travels through the gastrointestinal tract and controls the beam steering means and focusing means of the variable lens system to ensure that the light beams from the at least one light source are directed and focused onto the diseased tissue areas;

a power source for powering the image sensor, the at least one light source and the control unit; and

a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source;

causing the at least one light source to illuminate and excite the diseased tissue areas having bound fluorescent agent to transmit fluorescent light images to the lens system, image sensor and control unit;

wherein the control unit controls the variable lens focusing means and beam steering means to ensure illumination of the diseased areas by the at least one light source;

and causing the at least one light source to optically treat the diseased areas.

6. The method of claim 5, for in vivo treatment of one or more diseased tissue areas of interest within the gastrointestinal tract of an animal or human being comprising:

ingesting into the gastrointestinal tract a fluorescence marking agent that will chemically bind to the diseased tissue areas only and cause the diseased tissue areas to transmit fluorescent light beams when stimulated by a light source;

thereafter ingesting a capsule comprising;

an image sensor;

a lens system for focusing images of interest onto the image sensor;

first and second light sources for providing illumination to the tissue of the gastrointestinal tract;

wherein the second light source is a laser capable of providing optical therapeutic treatment to the diseased tissue areas;

a variable lens system located in front of the first light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the first light source onto the diseased tissue areas;

a control unit in communication with the image sensor, first and second light sources, and variable lens system, the control unit comprising image storing means, processing means and image transmission means;

wherein the control unit correlates stored images received from the image sensor as the capsule travels through the gastrointestinal tract and controls the beam steering means and focusing means of the variable lens system to ensure that the light beams from the first light source are directed and focused onto the diseased tissue areas;

a power source for powering the image sensor, the first and second light sources and the control unit; and

a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the first and second light sources, the variable lens system, the control unit and the power source;

causing the first light source to illuminate and excite the diseased tissue areas having bound fluorescent agent to transmit fluorescent light images to the lens system, image sensor and control unit;

wherein the control unit controls the variable lens focusing means and beam steering means to ensure illumination of the diseased areas by the first light source;

and causing the second light source to optically treat the diseased areas.

7. The method of claim 5, wherein the treatment comprises thermo-ablation of a lesion or tumor;

or coagulation of a bleeding blood vessel or bleeding tumor.