Device for increasing cerebral blood flow

• US 9,011,378 B2
• Filed: 04/29/2010
• Issued: 04/21/2015
• Est. Priority Date: 11/02/2007
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation, CS Therapeutics, Inc.
• Inventors: Luciano, Mark G., Dombrowski, Stephen M., Moran, Timothy
• Primary Examiner(s): Price, Nathan R
• Application Number:
  US12/770,276
• Publication Number:
  US 20110004158A1
• Time in Patent Office: 1,818 Days
• Field of Search: 604/31, 604 65- 67, 604131-133, 604/151, 604/153, 604503-506
• US Class Current: 604/153
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 2210/1003 Spinal column
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure
• CPC Class Codes: F04B 43/06 Pumps having fluid drive

Abstract

A device for regulating cerebrospinal fluid in a cerebrospinal fluid space includes a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid. An actively oscillatably changeable sealed fluid volume can be in fluid communication with the cerebrospinal conduit. The changeable sealed fluid volume can be in a sealed fluid path extending to the distal end of the cerebrospinal conduit and is capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space.

Claims

1. A device for regulating cerebrospinal fluid in a cerebrospinal fluid space comprising:

a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid;

an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being within an enclosed container, the container containing at least one of cerebrospinal fluid and saline fluid therein, a deformable fluid tight balloon having interior and exterior surfaces extending into the container, the balloon for expanding and deflating in volume size within the container for decreasing and increasing fluid volume size of the changeable sealed fluid volume, the container having a first port in communication with the changeable sealed fluid volume, the cerebrospinal conduit being coupled to the first port of the container, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit and capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space; and

pressure sensor elements positioned for sensing pressure within the chanegable sealed fluid volume and within the balloon for controlling oscillation parameters for oscillating the cerebrospinal fluid.

2. The device of claim 1 further comprising an actuator coupled to the changeable sealed fluid volume for oscillating the changing fluid volume size of the changeable sealed fluid volume.

3. The device of claim 2 further comprising a sensor system for sensing conditions of a patient, the sensor system being in communication with the actuator for controlling operation of the actuator.

4. The device of claim 3 in which the sensor system includes a control system for controlling operation of the actuator.

5. The device of claim 4 in which the operation of the actuator is synchronized with a biorhythm of the patient.

6. The device of claim 5 in which the biorythm is related to the patient'"'"'s heart.

7. The device of claim 5 in which the actuator is synchronized with a signal that is selected from the group consisting of an ECG signal, a pulse signal and a pressure signal.

8. The device of claim 4 in which the sensor system includes a sensor for sensing within the cerebrospinal fluid space for forming a feed back loop to control the level of cerebrospinal fluid within the cerebrospinal fluid space.

9. The device of claim 1 further comprising a fluid storage container coupled to the changeable sealed fluid volume and controllably fluidly isolated from the changeable sealed fluid volume.

10. The device of claim 1 in which application of an oscillating force on the interior surface of the balloon is capable of deforming the balloon to oscillate the changing fluid volume size of the changeable sealed fluid volume.

11. The device of claim 10 in which the container has a second port in communication with the interior surface of the balloon.

12. The device of claim 11 further comprising an oscillating pump coupled to the second port of the container for providing oscillating fluid pressure to the interior surface of the balloon.

13. A device for regulating cerebrospinal fluid in a cerebrospinal fluid space comprising:

a cerebrospinal conduit having a distal end for insertion into the cerebrospinal fluid space in fluid communication with the cerebrospinal fluid; and

an actively oscillatably changeable sealed fluid volume in fluid communication with the cerebrospinal conduit, the changeable sealed fluid volume being within an enclosed container, the container containing at least one of cerebrospinal fluid and saline fluid therein, a deformable fluid tight balloon having interior and exterior surfaces extending into the container, the balloon for expanding and deflating in volume size within the container for decreasing and increasing fluid volume size of the changeable sealed fluid volume, the container having a first port in communication with the changeable sealed fluid volume, the cerebrospinal conduit being coupled to the first port of the container, the changeable sealed fluid volume being in a sealed fluid path extending to the distal end of the cerebrospinal conduit and capable of actively oscillating in a changing fluid volume size for oscillating the cerebrospinal fluid in and out of the distal end of the cerebrospinal conduit and cerebrospinal fluid space;

an actuator coupled to the changeable sealed fluid volume for oscillating the changing fluid volume size of the changeable sealed fluid volume;

a control system for controlling operation of the actuator synchronized with a biorhythm; and

pressure sensor elements positioned for sensing pressure within the changeable sealed fluid volume and within the balloon for controlling oscillation parameters for oscillating the cerebrospinal fluid.