Device for delivering medicament

• US 9,011,386 B2
• Filed: 11/21/2005
• Issued: 04/21/2015
• Est. Priority Date: 06/01/2005
• Status: Active Grant

• Current Assignee: Shl Medical AG
• Original Assignee: SHL Group AB
• Inventors: Kronestedt, Victor, Brunnberg, Lennart, Olson, Stephan, Karlsson, Anders, Deurell, Tomas
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LANDRY II, GERALD ERNEST
• Application Number:
  US11/282,593
• Publication Number:
  US 20060276754A1
• Time in Patent Office: 3,438 Days
• Field of Search: 604/131, 604134-139, 604220-224, 604/228, 604/229, 604/186, 604/206
• US Class Current: 604/186
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0076 on a drum
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/202 cocking means, e.g. to bias the main drive spring of an injector
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31556 Accuracy improving means
• CPC Class Codes: A61M 5/3156 using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
• CPC Class Codes: A61M 5/31573 Accuracy improving means
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

The present invention relates to a device for the delivery of predetermined doses of liquid medicament to a patient, which medicament is intended to be inhaled by the patient or intended to be injected into the body of the patient. The device is adapted to be in a medicament delivery state and in a medicament non-delivery state. When the device is in a medicament delivery state, said device is adapted to drive a piston into a cartridge containing the liquid medicament to be delivered, with a force that is above or equal to a predetermined minimum force value and below a predetermined maximum force value. The minimum force value is the lowest force value needed to deliver the predetermined dose and the maximum force value is the first force value at which it exists a risk of damaging the cartridge or the components of the device.

Claims

1. A device for delivering predetermined doses of liquid medicament, which device is adapted to be in a medicament delivery state and in a medicament non-delivery state, comprising:

a cartridge adapted to contain the liquid medicament and a piston sealingly and slidably arranged in the cartridge;

an energy accumulating member;

an elongated screw threaded plunger rod adapted to be arranged in an interior of the device, wherein a proximal end of the plunger rod is adapted to be in contact with the piston, such that, when a first force from the energy accumulating member is applied to the plunger rod when the device is in the medicament delivery state, the plunger rod and the piston move toward a proximal end of the cartridge with a predetermined distance and expel a predetermined dose of the liquid medicament from the cartridge;

at least one additional rod that extends along a longitudinal axis of the device and that is in contact with the plunger rod, wherein a distal end of the at least one additional rod extends beyond a distal end of the device, and the at least one additional rod is adapted, upon activation, to be moved by a second force in the proximal direction of the device.

2. The device of claim 1, wherein during medicament delivery the device is adapted to be set in the medicament non-delivery state before an entire set dose has been delivered, whereupon the plunger rod stops moving toward the proximal end of the cartridge, and the device thereafter is adapted to be set in the medicament delivery state, whereupon the plunger rod continues to move the predetermined distance toward the proximal end of the device.

3. The device of claim 1, wherein the device is adapted to be connected to a medicament administering member, and the medicament administering member has a form of a mouth piece or a nasal piece that a patient can put in the patient'"'"'s mouth or nose, respectively, whereby the predetermined dose of medicament is inhaled by the patient when the delivery device is in the medicament delivery state.

4. The device of claim 1, wherein the device is adapted to be connected to a medicament administering member, and the medicament administering member has a form of a nozzle, whereby the predetermined dose of medicament is sprayed into a patient'"'"'s eye or onto the patient'"'"'s skin when the delivery device is in the medicament delivery state.

5. The device of claim 1, wherein the device is adapted to be connected to a medicament administering member, and the medicament administering member has a form of a member that can introduce the predetermined dose of medicament into a patient'"'"'s eye as at least one drop when the delivery device is in the medicament delivery state.

6. The device of claim 1, wherein the device is adapted to be connected to a medicament administering member, and the medicament administering member has a form of a needle for injecting the predetermined dose of medicament into a patient'"'"'s body when the delivery device is in the medicament delivery state.

7. The device of claim 1, wherein the plunger rod is a hollow plunger rod and the at least one additional rod is disposed inside and extending along a longitudinal axis of the hollow plunger rod.

8. The device of claim 1, wherein the second force is a manual force applied to the at least one additional rod by a user.

9. The device of claim 1, wherein the second force is an accumulated force applied by a resilient device.

10. The device of claim 9, wherein a distal end of the at least one additional rod is disposed within a housing provided on a distal end of the device, the housing is adapted to be rotated to a second position from a first position, the housing comprises a helical spring in contact with the at least one additional rod, the helical spring is in a compressed state when the housing is in the first position, and the helical spring is adapted to provide, when the housing is rotated to the second position, the at least one additional rod with the second force that drives the at least one additional rod toward the proximal end of the device.

11. The device of claim 1, wherein the second force that is applied to the at least one additional rod is applied before medicament delivery and corresponds to a force needed for the piston to start moving from an initial position in a distal end of the cartridge.

12. The device of claim 11, wherein the force that is applied to the at least one additional rod is applied before medicament delivery and corresponds to a force needed for initial priming of the device, calibration of the device, or mixing of medicament in the cartridge.

13. A device for delivering predetermined doses of liquid medicament, which device is adapted to be in a medicament delivery state and in a medicament non-delivery state, comprising:

a cartridge adapted to contain the liquid medicament and a piston sealingly and slidably arranged in the cartridge;

an energy accumulating member;

an elongated screw threaded plunger rod adapted to be arranged in an interior of the device, wherein a proximal end of the plunger rod is adapted to be in contact with the piston, such that, when a first force from the energy accumulating member is applied to the plunger rod when the device is in the medicament delivery state, the plunger rod and the piston move toward a proximal end of the cartridge with a predetermined distance and expel a predetermined dose of the liquid medicament from the cartridge;

at least one additional rod that extends along a longitudinal axis of the device and that is in contact with the plunger rod, wherein a distal end of the at least one additional rod extends beyond a distal end of the device, and the at least one additional rod is adapted, upon activation, to be moved by a second force in the proximal direction of the device; and

a dose setting member adapted to be rotated by at least one predetermined step when the device is in the medicament non-delivery state, wherein rotation of the dose setting member by one step increases a set dose by one step and also increases the accumulated energy in the energy accumulating member by one step.

14. The device of claim 13, wherein the energy accumulating member is adapted to accumulate energy in terms of at least one predetermined step when the device is in the medicament non-delivery state, which energy is adapted to be transferred to the plunger rod so that the plunger rod is provided with the force that drives the plunger rod and the piston the predetermined distance toward the proximal end of the cartridge when the device is in the medicament delivery state.

15. The device of claim 14, wherein the energy accumulating member is a spring capable of providing an output torque and the accumulated energy is energy that results from rotational tensioning of the spring, which accumulated energy is transferred to the output torque when the tensioning of the spring is released when the device is set in the medicament delivery state;

the output torque is adapted to be provided to a plunger rod driving member provided with a predetermined pitch of grooving that corresponds to the threads of the plunger rod; and

rotation of the plunger rod driving member due to the output torque of the spring drives the plunger rod without rotation the predetermined distance towards the proximal end of the cartridge with a predetermined force.

16. The device of claim 15, wherein the spring is a flat spiral spring.

17. The device of claim 14, wherein the energy accumulating member is a helical spring and the accumulated energy is energy that results from compression of the helical spring;

the accumulated energy is adapted to be transferred to the plunger rod when the device is in the medicament delivery state, so that the plunger rod moves with rotation toward the proximal end of the cartridge the predetermined distance; and

the cartridge is disposed in a cartridge housing that is provided with a thread with a predetermined pitch of grooving that corresponds to the thread of the plunger rod.

18. The device of claim 13, wherein cooperation between the predetermined energy of the energy accumulating member that is accumulated when the dose setting member is rotated and the thread on the plunger rod determines a predetermined force that is applied to the piston during medicament delivery.

19. The device of claim 13, wherein the device is adapted to be set to a default dose value to be delivered, and the dose setting member is adapted to be rotated only a predetermined number of steps that corresponds to the default dose value.