Method and device for micro-dosing a liquid

• US 9,011,390 B2
• Filed: 03/14/2013
• Issued: 04/21/2015
• Est. Priority Date: 12/18/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Haenggi, Roger, Niklaus, Hanspeter
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): Hall, Deanna K
• Application Number:
  US13/803,070
• Publication Number:
  US 20130221023A1
• Time in Patent Office: 768 Days
• Field of Search: 604/207, 604/211
• US Class Current: 604/207
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: B65D 83/0005 Containers or packages provided with a piston or with a movable bottom or partition having approximately the same section as the container B65D83/0072 takes precedence

Abstract

Methods and devices for micro-dosing a liquid are disclosed herein. According to one embodiment, a method for a time controlled micro-dosing of a liquid from a liquid reservoir includes: receiving the liquid reservoir with a structure wherein the structure is portable; securing the liquid reservoir to the structure; connecting a second end of a drive unit to a piston disposed within the liquid reservoir; activating a drive motor; displacing the drive unit with respect to the structure towards the piston in an axial direction with the drive motor; moving the piston axially within the liquid reservoir; and micro-dosing the liquid from the liquid reservoir.

Claims

1. A micro-dosing device for micro-dosing a liquid from a liquid reservoir, the micro-dosing device comprising:

a structure configured to receive a liquid reservoir;

a drive unit comprising a first end, a second end, and a drive motor;

a displacement piston configured to move axially and dispense the liquid from the liquid reservoir when the drive motor activates and axially displaces the drive unit relative to the structure and relative to a sleeve wherein the sleeve comprises an inner thread that engages the outer thread of a rotatable member and the rotatable member is coupled to the first end of the drive unit and comprises an outer thread coaxially arranged around an axis of rotation; and

an anti-rotation element disposed between the drive unit and the sleeve wherein the anti-rotation element prevents a rotation of the drive unit relative to the sleeve and permits an axial displacement of the drive unit relative to the sleeve and wherein the anti-rotation element extends radially outward from the periphery of the drive unit through a longitudinal slot formed through the structure and through the sleeve.

2. The micro-dosing device of claim 1 further comprising a flexprint coupled to the structure and arranged directly at the drive unit adjacent the anti-rotation element.

3. The micro-dosing device of claim 1 further comprising a flexprint coupled to the structure and configured to establish electrical connections between a computerized control unit, the drive motor, and an encoder.

4. The micro-dosing device of claim 1 wherein portions of the inner thread of the sleeve are facing towards the drive unit, and the portions span at least 180 degrees of a circumference of the drive unit.

5. The micro-dosing device of claim 1 further comprising an encoder coupled to the drive motor and configured to monitor a total or a relative number of revolutions of the drive shaft of the drive motor.

6. The micro-dosing device of claim 1 further comprising an encoder coupled to the drive motor and configured to monitor a relative angle of rotation of the drive shaft of the drive motor.

7. The micro-dosing device of claim 6 wherein the encoder is disposed within a coupling member that is coupled to the drive unit.

8. The micro-dosing device of claim 1 further comprising a force sensor connected to a computerized control unit coupled to the structure to permit the monitoring of forces that are exerted upon the displacement piston in operation such that an empty liquid reservoir can be detected.

9. The micro-dosing device of claim 1 further comprising a force sensor connected to a computerized control unit coupled to the structure to permit the monitoring of forces that are exerted upon the displacement piston in operation such that an occlusion in a liquid path downstream of the liquid reservoir can be detected.

10. The micro-dosing device of claim 1 further comprising a force sensor connected to a computerized control unit coupled to the structure to permit the monitoring of forces that are exerted upon the displacement piston in operation such that a disorder comprising a titled piston can be detected.

11. The micro-dosing device of claim 1 further comprising a computerized control unit coupled to the structure that controls a time-controlled dispensation of liquid by the drive unit and which is functionally connected to an encoder to form a closed loop.

12. The micro-dosing device of claim 1 further comprising a computerized control unit coupled to the structure that controls a time-controlled dispensation of liquid by the drive unit and which is functionally connected to an encoder to establish an alarm function.

13. The micro-dosing device of claim 1 further comprising a computerized control unit coupled to the structure that activates the drive motor according to a specific activity profile provided by an electronic control system for a time-controlled dispensing of liquid from the liquid reservoir.

14. The micro-dosing device of claim 1 further comprising a sealing member coupled to the sleeve and configured so as to prevent dirt and liquid from entering the sleeve and an area between the sleeve and the structure, and wherein the sealing member is an O-ring.

15. The micro-dosing device of claim 1 wherein the sleeve comprises at its outer periphery a radially protruding rim.

16. The micro-dosing device of claim 1 further comprising a reduction gear comprising a power intake side that is coupled to the drive shaft of the drive motor and a power output side that is coupled to the rotatable member.

17. A method for a time controlled micro-dosing of a liquid from a liquid reservoir, the method comprising:

providing a portable structure containing a liquid reservoir secured to the portable structure wherein the structure contains a drive unit connected to a displacement piston disposed within the liquid reservoir, wherein the drive unit has a drive motor, and wherein the drive unit comprises an anti-rotation element that extends radially outward from the periphery of the drive unit through a longitudinal slot formed through the structure and through a sleeve coupled to the structure; and

micro-dosing the liquid from the liquid reservoir by activating the drive motor so as to move the displacement piston axially within the liquid reservoir by rotating with the drive unit a rotatable member coupled to the drive unit, the rotatable member having an outer thread which engages an inner thread disposed on the sleeve, and arranged between the drive unit and the second member is the anti-rotation element preventing rotation of the drive unit relative to the sleeve and permitting axial displacement of the drive unit relative to the sleeve.

18. The method of claim 17 wherein the portable structure further comprises an encoder coupled to the drive motor and wherein a total or a relative number of revolutions of the drive shaft of the drive motor is monitored using the encoder.

19. The method of claim 17 wherein the portable structure further comprises an encoder coupled to the drive motor and wherein a relative angle of rotation of the drive shaft of the drive motor is monitored using an encoder.

20. The method of claim 17 wherein the portable structure further comprises a computerized control unit coupled to the portable structure that controls the time-controlled micro-dosing of the liquid by the drive unit and which is functionally connected to an encoder to establish an alarm function.