Broad wavelength profile to homogenize the absorption profile in optical stimulation of nerves

• US 9,011,508 B2
• Filed: 07/21/2012
• Issued: 04/21/2015
• Est. Priority Date: 11/30/2007
• Status: Active Grant

• Current Assignee: Nurotone Medical Ltd.
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Stafford, Ryan C.
• Primary Examiner(s): Crandall, Lynsey
• Assistant Examiner(s): PAHAKIS, MANOLIS Y
• Application Number:
  US13/555,092
• Publication Number:
  US 20130023960A1
• Time in Patent Office: 1,004 Days
• Field of Search: 607/137
• US Class Current: 607/89
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/36039 fitting procedures
• CPC Class Codes: A61N 2005/0605 Ear
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/067 using laser light
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

The present invention provides an apparatus that includes an infrared (IR) light source having two or more wavelengths (e.g., a relatively broad wavelength-profile light source and/or a light source with a plurality of relatively narrowband wavelengths), wherein the different wavelengths have different tissue-penetration depths. The IR light provides optical stimulation of nerves to generate nerve-action potentials (NAPs) in one or more individual nerve cells, and/or compound nerve-action potentials (CNAPs) in a nerve bundle. In some embodiments, the stimulation of NAPs and CNAPs is used to restore hearing. In some embodiments, the broad wavelength profile extends the physical volume of tissue that is stimulated, thus homogenizing the spatial light-absorption profile of the stimulation light used, e.g., for optical triggering of NAPs and CNAPs in the cochlea.

Claims

1. An apparatus for optically stimulating a neural tissue in a cochlea of a person in order to trigger a compound nerve-action-potential (CNAP) response that evokes sensations for the person without damaging the neural tissue, wherein the neural tissue includes a plurality of neural tissue types at different tissue depths including a first type at a first tissue depth having a first optical-absorption coefficient at a first wavelength, a second type at a second tissue depth having a second optical-absorption coefficient at a second wavelength, and a third type at a third tissue depth that has a third optical-absorption coefficient at a third wavelength, wherein the third neural tissue type is located between the first depth and the second depth, wherein application of a first predetermined amount of energy at the first wavelength has a first effectiveness in triggering a CNAP in the neural tissue, wherein application of the second predetermined amount of energy at the second wavelength has a second effectiveness in triggering a CNAP in the neural tissue, and wherein the first wavelength is different than the second wavelength, the apparatus comprising:

means for generating a broad-band optical stimulation signal comprising a plurality of pulsed narrow-band optical stimulation signals, each having an optical-signal-energy amount at a different wavelength, the broad-band optical stimulation signal including a first optical-signal-energy amount at the first wavelength and a second optical-signal-energy amount at the second wavelength, wherein the second wavelength differs from the first wavelength by at least 5 nm, and wherein the means for generating includes;

means for emitting the plurality of pulsed narrow-band optical stimulation signals including a first, a second and a third narrow-band laser capable of emitting optical stimulation signals at the first, the second and the third wavelengths, respectively;

means for combining the plurality of pulsed narrow-band optical stimulation signals to form the broad-band optical-stimulation signal; and

means for delivering the broad-band optical-stimulation signal to the neural tissue of the person, wherein the delivered signal triggers, in the neural tissue, one or more CNAP responses to the delivered signal, and wherein the delivered broad-band optical-stimulation signal has an effectiveness in triggering a CNAP in the neural tissue that is greater than the first effectiveness, and greater than the second effectiveness;

and means for controlling the means for emitting the plurality of pulsed narrow-band optical stimulation signals configured to dynamically vary over time the optical-energy-amount of each of the plurality of narrow-band optical stimulation signals independently, wherein the means for controlling is configured to control, at a first time, the first, the second and the third narrow-band lasers so that the broad-band optical-stimulation signal triggers nerve-action-potentials (NAPs) at both the first and the second depths, but does not trigger NAPs at the third depth, and to control, at a second time, the first, the second, and the third narrow-band lasers so that the broad-band optical-stimulation signal triggers NAPs at the first, the second and the third depths equally.

2. The apparatus of claim 1, wherein the means for delivering the broad-band optical stimulation signal includes means for delivering the broad-band optical-stimulation signal to one or more neurons of an auditory-nerve pathway of the person.

3. The apparatus of claim 1, wherein in a first neural tissue the first optical-absorption coefficient at the first wavelength is smaller than the second optical-absorption coefficient at the second wavelength, wherein, at a third time, the first energy amount at the first wavelength is larger than the second energy amount at the second wavelength in order to enhance triggering one or more NAPs in the first tissue;

and

wherein the means for generating further generates, at a fourth time, a second broad-band optical-stimulation signal having optical-signal-energy amounts at a plurality of different wavelengths including a third optical-signal-energy amount at the first optical-absorption wavelength and a fourth optical-signal-energy amount at the second optical-absorption wavelength; and

wherein the means for delivering further delivers the second broad-band optical-stimulation signal to a second neural tissue of the person, wherein in the second tissue the first optical-absorption coefficient at the first wavelength is larger than the second optical-absorption coefficient at the second wavelength, wherein the second pulsed optical-stimulation signal has the third energy amount at the first wavelength and the fourth energy amount at the second wavelength, wherein the third energy amount at the first wavelength is smaller than the fourth energy amount at the second wavelength, and wherein the delivered second broad-band optical-stimulation signal selectively triggers, in the second neural tissue, one or more nerve-action-potential responses to the delivered signal.

4. The apparatus of claim 1, wherein the means for delivering is adapted to be implanted in the cochlea of the person.

5. The apparatus of claim 1,

wherein the neural tissue is in an auditory-nerve pathway of the person,

wherein the person perceives a dynamic hearing range as a result of the broad-band optical-stimulation signal at different times,

wherein the person perceives a first perceived sound level at a third time when the broad-band optical-stimulation signal has a first ratio of optical-signal energy at the first wavelength to optical-signal energy at the second wavelength and has a first total energy at the third time,

wherein the person perceives a second perceived sound level at a fourth time if the first broad-band optical-stimulation signal has a second ratio of optical-signal energy at the first wavelength to optical-signal energy at the second wavelength and has a second total energy at the second time,

wherein the first ratio is not equal to the second ratio, and

wherein the first and second ratios are chosen to increase the dynamic hearing range perceived by the person.

6. The apparatus of claim 1, wherein the first, the second and the third wavelengths are in the infrared range.

7. The apparatus of claim 1, wherein the apparatus includes an audio processor.

8. The apparatus of claim 1, wherein the neural tissue is the spiral ganglion cells of the cochlea of the person.

9. An apparatus for optically stimulating a neural tissue in a cochlea of a person in order to trigger a compound nerve-action-potential (CNAP) response that evokes sensations for the person without damaging the neural tissue, wherein the neural tissue includes a plurality of neural tissue types at different tissue depths including a first type at a first tissue depth having a first optical-absorption coefficient at a first wavelength, a second type at a second tissue depth having a second optical-absorption coefficient at a second wavelength, and a third type at a third tissue depth that has a third optical-absorption coefficient at a third wavelength, wherein the third neural tissue type is located between the first depth and the second depth, wherein application of a first predetermined amount of energy at the first wavelength has a first effectiveness in triggering a CNAP in the neural tissue, wherein application of the second predetermined amount of energy at the second wavelength has a second effectiveness in triggering a CNAP in the neural tissue, and wherein the first wavelength is different than the second wavelength, the apparatus comprising:

an optical generator configured to output a broad-band optical stimulation signal comprising a plurality of pulsed narrow-band optical stimulation signals, each having an optical-signal-energy amount at a different wavelength, the broad-band optical stimulation signal including a first optical-signal-energy amount at the first wavelength and a second optical-signal-energy amount at the second wavelength, wherein the second wavelength differs from the first wavelength by at least 5 nm, and wherein the optical generator includes;

a plurality of narrow-band lasers for emitting the plurality of pulsed narrow-band optical stimulation signals, wherein the plurality of narrow-band lasers includes a first, a second and a third narrow-band laser capable of emitting optical stimulation signals at the first, the second and the third wavelengths, respectively;

a beam combiner configured to combine the plurality of pulsed narrow-band optical stimulation signals to form the broad-band optical-stimulation signal; and

an optical guide configured to deliver the broad-band optical-stimulation signal to the neural tissue of the person, wherein the delivered signal triggers, in the neural tissue, one or more CNAP responses to the delivered signal, and wherein the delivered broad-band optical-stimulation signal has an effectiveness in triggering a CNAP in the neural tissue that is greater than the first effectiveness, and greater than the second effectiveness;

and a controller configured to dynamically vary over time the optical-energy-amount of each of the plurality of narrow-band optical stimulation signals independently, wherein the controller is configured to control, at a first time, the first, the second and the third narrow-band lasers so that the broad-band optical-stimulation signal triggers nerve-action-potentials (NAPs) at both the first and the second depths, but does not trigger NAPs at the third depth, and to control, at a second time, the first, the second, and the third narrow-band lasers so that the broad-band optical-stimulation signal triggers NAPs at the first, the second and the third depths equally.

10. The apparatus of claim 9, wherein the optical guide is configured to deliver the broad-band optical-stimulation signal to one or more neurons of an auditory-nerve pathway of the person.

11. The apparatus of claim 9, wherein the first optical-absorption coefficient at the first wavelength is smaller than the second optical-absorption coefficient at the second wavelength, and wherein the first energy amount at the first wavelength is larger than the second energy amount at the second wavelength.

12. The apparatus of claim 9, wherein the optical generator is configured to output the broad-band optical-stimulation signal with a first pulse shape at the first wavelength and a second pulse shape at the second wavelength, wherein the pulse shape of the signal at the first wavelength is different than the pulse shape of the signal at the second wavelength, and wherein pulse shape is defined as the amount of power as a function of time.

13. The apparatus of claim 9, wherein the optical generator is configured to output the broad-band optical-stimulation signal with a first pulse at the first wavelength that ends at a first ending point in time and a second pulse at the second wavelength that ends at a second ending point in time, wherein the first ending point of the signal at the first wavelength is different than the second ending point of the signal at the second wavelength, and, wherein the optical generator is further configured to output the broad-band optical-stimulation signal with a first spot size at the first wavelength and a second spot size at the second wavelength, wherein the spot size of the signal at the first wavelength is different than the spot size of the signal at the second wavelength.

14. The apparatus of claim 9, wherein the first optical-absorption coefficient at the first wavelength is smaller than the second optical-absorption coefficient at the second wavelength, and wherein the first energy amount at the first wavelength is larger than the second energy amount at the second wavelength, and wherein the first wavelength is longer than the second wavelength.

15. The apparatus of claim 9, wherein the second optical-absorption wavelength differs from the first optical-absorption wavelength by at least 10 nm.

16. The apparatus of claim 9, wherein the spectral bandwidth of the plurality of wavelengths of the broad-band optical-stimulation signal is at least 10 nm and no more 100 nm.

17. The apparatus of claim 9, wherein the spectral bandwidth of the plurality of wavelengths of the broad-band optical-stimulation signal is between 15 nm and 20 nm.

18. The apparatus of claim 9, wherein the optical guide is adapted to be implanted in the cochlea of the person.

19. The apparatus of claim 9, wherein the first, the second and the third wavelengths are in the infrared wavelength range.

20. The apparatus of claim 9, wherein in a first neural tissue the first optical-absorption coefficient at the first wavelength is smaller than the second optical-absorption coefficient at the second wavelength, wherein, at a third time, the first energy amount at the first wavelength is larger than the second energy amount at the second wavelength in order to enhance triggering one or more NAPs in the first tissue;

and wherein the optical generator is further configured to generate, at a fourth time, a second broad-band optical-stimulation signal having optical-signal-energy amounts at a plurality of different wavelengths including a third optical-signal-energy amount at the first optical-absorption wavelength and a fourth optical-signal-energy amount at the second optical-absorption wavelength; and

wherein the optical guide is further configured to deliver the second broad-band optical-stimulation signal to a second neural tissue of the person, wherein in the second tissue the first optical-absorption coefficient at the first wavelength is larger than the second optical-absorption coefficient at the second wavelength, wherein the second pulsed optical-stimulation signal has the third energy amount at the first wavelength and the fourth energy amount at the second wavelength, wherein the third energy amount at the first wavelength is smaller than the fourth energy amount at the second wavelength, and wherein the delivered second broad-band optical-stimulation signal preferentially triggers, in the second neural tissue, one or more nerve-action-potential responses to the delivered signal.

21. The apparatus of claim 9, wherein the first optical-signal-energy amount of the first signal at the first wavelength is the same as the second optical-signal-energy amount of the first signal at the second wavelength.

22. The apparatus of claim 9, wherein the neural tissue is the spiral ganglion cells of the cochlea.

23. The apparatus of claim 9, wherein the apparatus includes an audio processor.