Individually optimized performance of optically stimulating cochlear implants

• US 9,011,509 B2
• Filed: 07/21/2012
• Issued: 04/21/2015
• Est. Priority Date: 11/30/2007
• Status: Active Grant

• Current Assignee: Nurotone Medical Ltd.
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Stafford, Ryan C., Wells, Jonathon D., Stafford, James W., Norton, Bryan J.
• Primary Examiner(s): Crandall, Lynsey
• Assistant Examiner(s): PAHAKIS, MANOLIS Y
• Application Number:
  US13/555,093
• Publication Number:
  US 20130023961A1
• Time in Patent Office: 1,004 Days
• Field of Search: None
• US Class Current: 607/89
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/36039 fitting procedures
• CPC Class Codes: A61N 2005/0605 Ear
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/067 using laser light
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

Method and apparatus for optically stimulating neurons of a plurality of auditory nerve pathways of a person to provide auditory sensations for the person including generating a plurality of pulsed light signals having one or more successive pulses; delivering the plurality of pulsed light signals to one or more auditory nerve pathways of the cochlea of the person; selectively controlling the plurality of light signals to optically stimulate and trigger nerve action potentials (NAPs) in the one or more auditory nerve pathways, wherein the selectively controlling includes empirically testing the delivering of the plurality of light signals and determining which optical-stimulation parameters used during the testing are most effective for optically stimulating the auditory nerve pathways of the person, and using results of the testing such that the delivering includes delivering the plurality of light signals with the optical-stimulation parameters that were determined to be most effective for optically stimulating.

Claims

1. An implanted apparatus for optically stimulating neurons of a cochlea of a person to provide auditory sensations for the person, the implanted apparatus comprising:

means for calibrating in a calibration mode, wherein the means for calibrating includes;

means for generating a plurality of pulsed light signals each having a plurality of successive pulses that, when applied to a neuron of a person, will each stimulate a nerve action potential (NAP) in the neuron,

means for delivering each one of the plurality of light signals to a different one of a plurality of locations in the cochlea of the person, wherein the means for generating and the means for delivering are configured to be implanted in the cochlea of the person, and

means for selectively controlling the plurality of light signals to optically stimulate one or more neurons at the respective one of the plurality of locations in the cochlea in order to trigger NAPs in the one or more neurons of the cochlea, and

means for empirically testing the delivering of the plurality of light signals, wherein the means for empirically testing is configured to vary and determine one or more values, for each of a plurality of variable optical-stimulation parameters, that is most effective for optically stimulating the one or more neurons of the cochlea of the person having the implanted apparatus based on perceived-sensation feedback from the person, wherein the perceived-sensation feedback includes a speech recognition score or a loudness comfort-level, wherein the plurality of varied parameters includes a spectral wavelength and a polarization of the plurality of light signals; and

means for providing an audio perception in a first listening mode, wherein the means for providing the audio perception includes;

means for receiving an audio signal, the means for generating, further configured to generate, based on the received audio signal, a plurality of pulsed light signals having one or more successive pulses and, based on results from the means for testing, using the one or more values for each one of the plurality of optical-stimulation parameters that was determined to be most effective for optically stimulating the one or more neurons of the cochlea, and

the means for delivering, further configured to deliver the plurality of light signals to the one or more neurons of the cochlea using the one or more values for each one of the plurality of optical-stimulation parameters that was determined to be most effective for optically stimulating the one or more neurons of the cochlea.

2. The apparatus of claim 1, wherein the means for empirically testing includes means for eliciting and receiving input from the person, and based on the input, for determining a speech-recognition score for each of a plurality of values for each of the plurality of optical-stimulation parameters used during the testing.

3. The apparatus of claim 1, wherein the means for empirically testing includes means for eliciting and receiving feedback from the person as to a physical-comfort level of the person at each of a plurality of values for each of the plurality of optical-stimulation parameters used during the testing.

4. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more light-signal-pulse-width values that is most effective for optically stimulating the one or more neurons of the cochlea.

5. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more light-signal-pulse-repetition-rate values that is most effective for optically stimulating the one or more neurons of the cochlea.

6. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more audio-signal-processing-filter-bandwidth values, one or more audio-signal-processing-filter-shape values, and one or more audio-signal-processing-filter-center-frequency values that are most effective for optically stimulating the one or more neurons of the cochlea.

7. The apparatus of claim 1, wherein the means for generating the plurality of light signals includes means for grouping one or more of the plurality of light signals into each one of a plurality of optical-stimulation channels, and wherein the selectively controlling includes means for determining which optical-stimulation channels are most effective in triggering auditory sensations at each of a plurality of perceived frequencies, and thereafter using certain channels determined to be most effective and not using certain other channels.

8. The apparatus of claim 1, wherein the means for generating include a vertical-cavity surface-emitting laser.

9. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more light-signal-pulse-beam-profile values that is most effective for optically stimulating the one or more neurons of the cochlea.

10. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more light-signal-pulse-beam-angle values that is most effective for optically stimulating the one or more neurons of the cochlea.

11. An implanted apparatus for optically stimulating neurons of a cochlea of a person to provide auditory sensations for the person, the implanted apparatus comprising:

a calibration system that includes;

a plurality of optical generators that generate a plurality of pulsed light signals each having a plurality of successive pulses that, when applied to a neuron of a person, will each stimulate a nerve action potential (NAP) in the neuron,

an optical guide configured to deliver each one of the plurality of light signals to a different one of a plurality of locations in the cochlea of the person, wherein the plurality of optical generators and the optical guide are configured to be implanted in the cochlea of the person,

and a controller configured to;

selectively control the plurality of light signals to optically stimulate one or more neurons at the respective one of the plurality of locations in the cochlea in order to trigger NAPs in the one or more neurons of the cochlea, and

empirically test the delivery of the plurality of light signals by the optical guide and vary and determine one or more values, for each of a plurality of variable optical-stimulation parameters, that is most effective for optically stimulating the one or more neurons of the cochlea of the person having the implanted apparatus based on perceived-sensation feedback from the person, wherein the perceived-sensation feedback includes a speech recognition score or a loudness comfort-level, wherein the plurality of varied parameters includes a spectral wavelength and a polarization of the plurality of light signals; and

a first-listening-mode system that includes;

an audio sensor configured to receive an audio signal, the optical generator further configured to generate, based on the received audio signal, a plurality of pulsed light signals having one or more successive pulses and to use the results of the empirical test, wherein a plurality of pulsed light signals have the one or more values for each one of the plurality of optical-stimulation parameters that was determined to be most effective for optically stimulating the one or more neurons of the cochlea, and the optical guide further configured to deliver the plurality of light signals using the one or more values for each one of the plurality of optical-stimulation parameters that was determined to be most effective for optically stimulating the one or more neurons of the cochlea.

12. The apparatus of claim 11, wherein the calibration system is further configured to elicit and receive input from the person, and based on the input, to determine a speech-recognition score for each of a plurality of values for each of the plurality of optical-stimulation parameters used during the testing and determine the one or more values most effective for optically stimulating the one or more neurons of the cochlea.

13. The apparatus of claim 11, wherein the calibration system is further configured to elicit and receive feedback from the person as to a loudness-comfort level of the person at each of a plurality of values for each of the plurality of optical-stimulation parameters used during the testing and determine the one or more values most effective for optically stimulating the one or more neurons of the cochlea.

14. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more light-signal-pulse-width values that is most effective for optically stimulating the one or more neurons of the cochlea.

15. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more light-signal-pulse-repetition-rate values that is most effective for optically stimulating the one or more neurons of the cochlea.

16. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more signal-processing-filter-bandwidth values and one or more signal-processing-filter-shape values that are most effective for optically stimulating the one or more neurons of the cochlea.

17. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more light-signal-pulse-amplitude values that is most effective for optically stimulating the one or more neurons of the cochlea.

18. The apparatus of claim 11, wherein the plurality of optical generators include a vertical-cavity surface-emitting laser.

19. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more light-signal-pulse-beam-profile values that is most effective for optically stimulating the one or more neurons of the cochlea.

20. The apparatus of claim 11, wherein the calibration system is further configured to determine one or more light-signal-pulse-beam-angle values that is most effective for optically stimulating the one or more neurons of the cochlea.