Compositions and methods
First Claim
1. A method of treating or inhibiting a dysbiosis, comprising administering an effective amount of a composition consisting of a population of germinatable bacterial spores and a pharmaceutically acceptable excipient to a subject, wherein the effective amount of the composition administered to the subject populates the gastrointestinal tract in the subject and augments growth of at least one type of bacteria not detectably present in the composition or in the gastrointestinal tract prior to administration, thereby treating the dysbiosis, inhibiting the dysbiosis, or reducing a severity of at least one symptom of the dysbiosis in the subject.
3 Assignments
0 Petitions
Accused Products
Abstract
Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
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Citations
28 Claims
- 1. A method of treating or inhibiting a dysbiosis, comprising administering an effective amount of a composition consisting of a population of germinatable bacterial spores and a pharmaceutically acceptable excipient to a subject, wherein the effective amount of the composition administered to the subject populates the gastrointestinal tract in the subject and augments growth of at least one type of bacteria not detectably present in the composition or in the gastrointestinal tract prior to administration, thereby treating the dysbiosis, inhibiting the dysbiosis, or reducing a severity of at least one symptom of the dysbiosis in the subject.
- 2. A method of treating or inhibiting a dysbiosis in a subject, comprising administering a composition consisting of a population of germinatable bacterial spores and a pharmaceutically acceptable excipient, wherein the population of germinatable bacterial spores is produced by a) providing a fecal material and b) subjecting the fecal material to a treatment resulting in purification of germinatable bacterial spores in an amount effective to treat the dysbiosis, inhibit the dysbiosis, or reduce a severity of at least one symptom of the dysbiosis in the subject.
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3. A method of treating or preventing a dysbiosis in a subject, comprising:
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obtaining a fecal material; treating the fecal material to obtain a purified population of spore-forming bacteria; generating from the purified population a composition of spore-forming bacteria consisting of a population of germinatable bacterial spores; and administering the composition to a subject in an amount effective to treat the dysbiosis, prevent the dysbiosis, or reduce the severity of at least one symptom of the dysbiosis in the subject. - View Dependent Claims (4, 5, 6, 7, 25, 26, 27, 28)
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Specification