Thermoreversible network scaffolds and methods of preparing same

• US 9,012,127 B2
• Filed: 11/29/2011
• Issued: 04/21/2015
• Est. Priority Date: 11/29/2010
• Status: Expired due to Fees

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Bowman, Christopher, Kloxin, Christopher J., Adzima, Brian J.
• Primary Examiner(s): SULLIVAN, CALEEN O
• Application Number:
  US13/820,608
• Publication Number:
  US 20130244179A1
• Time in Patent Office: 1,239 Days
• Field of Search: 430/325, 430/270.1, 430/311, 430/322, 430/283.1, 522/127
• US Class Current: 430/270.1
• CPC Class Codes: B29C 41/22 Making multilayered or multicoloured articles
• CPC Class Codes: C08F 234/02 in a ring containing oxygen coumarone-indene polymers C08F244/00
• CPC Class Codes: C08G 2261/46 Diels-Alder reactions
• CPC Class Codes: C08G 61/12 Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• CPC Class Codes: G03F 7/0037 Production of three-dimensional images
• CPC Class Codes: G03F 7/038 Macromolecular compounds which are rendered insoluble or differentially wettable G03F7/075 takes precedence; macromolecular azides G03F7/012; macromolecular diazonium compounds G03F7/021
• CPC Class Codes: G03F 7/38 Treatment before imagewise removal, e.g. prebaking G03F7/265 takes precedence

Abstract

The invention includes a novel light-activated polymerizable composition, wherein reversible crosslinks may be converted into irreversible crosslinks using a fully controllable physical and/or chemical process. The invention further includes methods of photofixing a light sensitive material or patterning an article comprising a light sensitive material.

Claims

1. A composition comprising at least one reversibly crosslinked polymer and at least one fixing molecule,

wherein the at least one reversibly crosslinked polymer comprises at least one crosslink,

wherein the at least one crosslink is formed by a reversible crosslinking reaction and comprises at least one chemical group that may react with the fixing molecule,

wherein the reaction between the fixing molecule and the at least one chemical group of the at least one crosslink prevents the at least one crosslink from undergoing the reverse crosslinking reaction,

wherein the composition optionally further comprises at least one photoinitiator.

2. The composition of claim 1,

wherein the at least one crosslink comprises an adduct,

wherein the adduct is formed by a Diels-Alder reaction between a diene-containing reactant and a dienophile-containing reactant, and

wherein the at least one chemical group of the crosslink is the double bond formed by the Diels-Alder reaction.

3. The composition of claim 2, wherein the diene-containing reactant comprises a diene selected from the group consisting of furan, cyclopentadiene, fulvene, anthracene, acyclic cis-1,3-butadiene, and combinations thereof.

4. The composition of claim 2, wherein the dienophile-containing reactant comprises a dienophile selected from the group consisting of maleimide, cyclopentadiene, cyanoethene, and combinations thereof.

5. The composition of claim 1, wherein the reaction between the fixing molecule and the at least one chemical group of the at least one crosslink is catalyzed, triggered or induced by electromagnetic irradiation.

6. The composition of claim 1, wherein the fixing molecule comprises a thiol group.

7. The composition of claim 1, wherein the photoinitiator comprises a Type (I) or Type (II) photoinitiator.

8. A method of photofixing a section of a light sensitive material, comprising the steps of:

providing a light sensitive material comprising at least one reversibly crosslinked polymer and at least one fixing molecule,

wherein the at least one reversibly crosslinked polymer comprises at least one reversible covalent crosslink,

wherein the material optionally further comprises at least one photoinitiator;

exposing a section of the material to electromagnetic radiation for a given period of time and at given intensity as to induce a fixing reaction between the at least one reversible covalent crosslink and the at least one fixing molecule,

wherein the fixing reaction causes a covalent modification of the at least one reversible covalent crosslink and prevents the at least one reversible covalent crosslink from undergoing the reverse crosslinking reaction,

whereby the section of the light sensitive material is photofixed.

9. The method of claim 8, wherein the at least reversible covalent crosslink comprises a Diels-Alder adduct, wherein the adduct is formed by a reaction between a diene-containing reactant and a dienophile-containing reactant.

10. The method of claim 9, wherein the diene-containing reactant comprises a diene selected from the group consisting of furan, cyclopentadiene, fulvene, anthracene, acyclic cis-1,3-butadiene, and combinations thereof.

11. The method of claim 9, wherein the dienophile-containing reactant comprises a dienophile selected from the group consisting of maleimide, cyclopentadiene, cyanoethene, and combinations thereof.

12. The method of claim 8, wherein the fixing molecule comprises a thiol group.

13. The method of claim 8, wherein the photoinitiator comprises a Type (I) or Type (II) photoinitiator.

14. The method of claim 13, wherein the removing of the depolymerized material of step (v) comprises solvent extraction, vacuum treatment, heating, and combinations thereof.

15. A method of patterning an article, wherein the article comprises a light sensitive material, wherein the method comprises the steps of:

(i) providing a first light sensitive composition comprising at least one reversibly crosslinked polymer and at least one fixing molecule,

wherein the at least one reversibly crosslinked polymer comprises at least one reversible covalent crosslink,

wherein the composition optionally further comprises at least one photoinitiator;

(ii) exposing a section of the first light sensitive composition to electromagnetic radiation for a given period of time and at given intensity as to induce a fixing reaction between the at least one reversible covalent crosslink and the fixing molecule,

wherein the fixing reaction causes a covalent modification of the at least one reversible covalent crosslink and prevents the at least one reversible covalent crosslink from undergoing the reverse crosslinking reaction,

thereby generating an article wherein the section of the first light sensitive composition is photofixed;

(iii) optionally performing the steps of;

providing at least one additional light sensitive composition comprising at least one reversibly crosslinked polymer and at least one fixing molecule, wherein the at least one reversibly crosslinked polymer comprises at least one reversible covalent crosslink, wherein the composition optionally further comprises at least one photoinitiator;

contacting the at least one additional light sensitive composition with the article of step (ii) as to generate a modified article;

exposing a section of the modified article to electromagnetic radiation for a given period of time and at given intensity as to induce a fixing reaction between the at least one reversible covalent crosslink and the fixing molecule, wherein the fixing reaction causes a covalent modification of the at least one reversible covalent crosslink and prevents the at least one reversible covalent crosslink from undergoing the reverse crosslinking reaction,

whereby the section of the modified article material is photofixed; and

,

repeating step (iii) until an article of desired shape and composition is prepared;

(iv) submitting the article of step (ii) or (iii) to a depolymerization process which induces the material that is not photofixed to undergo a reverse crosslinking reaction, thereby generating depolymerized material; and

,

(v) removing the depolymerized material from the article, thereby generating pattern features in the article.

16. The method of claim 15, wherein the at least one reversible covalent crosslink comprises a Diels-Alder adduct, wherein the adduct is formed by a reaction between a diene-containing reactant and a dienophile-containing reactant.

17. The method of claim 16, wherein the diene-containing reactant comprises a diene selected from the group consisting of furan, cyclopentadiene, fulvene, anthracene, acyclic cis-1,3-butadiene, and combinations thereof.

18. The method of claim 16, wherein the dienophile-containing reactant comprises a dienophile selected from the group consisting of maleimide, cyclopentadiene, cyanoethene, and combinations thereof.

19. The method of claim 15, wherein the fixing molecule comprises a thiol group.

20. The method of claim 15, wherein the photoinitiator comprises a Type (I) or Type (II) photoinitiator.

21. The method of claim 15, wherein the depolymerization process of step (iv) comprises heating, cooling, application of electromagnetic radiation, vacuum treatment, solvent extraction, and combinations thereof.