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Controlled release of growth factors and signaling molecules for promoting angiogenesis

  • US 9,012,399 B2
  • Filed: 06/01/2009
  • Issued: 04/21/2015
  • Est. Priority Date: 05/30/2008
  • Status: Active Grant
First Claim
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1. A method of inducing growth of new blood vessels either from existing blood vessels, or creation of de novo vessels, or a combination thereof, in a target tissue of a mammal, comprising contacting a mammalian cell by injecting into a tissue a device comprising an alginate hydrogel scaffold composition comprising N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) and vascular endothelial growth factor (VEGF), wherein said scaffold composition temporally controls release of the DAPT and the VEGF, wherein the VEGF said bioactive composition induces angiogenesis, arteriogenesis, or vasculogenesis, and wherein the VEGF comprises VEGF121, VEGF145, VEGF165, VEGF189, or VEGF206.

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