Multi-parametric fluid determination systems using complex admittance

• US 9,014,775 B2
• Filed: 09/03/2010
• Issued: 04/21/2015
• Est. Priority Date: 03/10/2008
• Status: Active Grant

• Current Assignee: James W. Bennett, Leonid Matsiev
• Original Assignee: S.E.A. Medical Systems Inc.
• Inventors: Bennett, James W., Matsiev, Leonid F.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): PATEL, SHEFALI DILIP
• Application Number:
  US12/875,939
• Publication Number:
  US 20110060198A1
• Time in Patent Office: 1,691 Days
• Field of Search: 600/309, 600/310, 600/345, 600/348, 600/547, 604/500, 604/506, 604/507, 604/503, 604/504
• US Class Current: 600/348
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/331 used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
• CPC Class Codes: A61M 2205/3313 used specific wavelengths
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2209/02 Equipment for testing the apparatus
• CPC Class Codes: A61M 5/168 Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body flow control in general G05D7/00
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G01N 21/17 Systems in which incident light is modified in accordance with the properties of the material investigated where the material investigated is optically excited causing a change in wavelength of the incident light G01N21/63
• CPC Class Codes: G01N 27/02 by investigating impedance
• CPC Class Codes: G01N 27/026 Dielectric impedance spectroscopy electrochemical impedance spectroscopy for measuring corrosion G01N17/02
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

An apparatus, systems, and methods related to determining an identity and a concentration of an intravenous fluid. The apparatus, the systems, and the methods described herein may provide near real-time monitoring and/or determination of an identity of components of the intravenous fluid. A concentration and the identity of all of the components of the intravenous fluid may be identified simultaneously.

Claims

1. A method for determining an identity and a concentration of an intravenous fluid by detecting fluid interactions at first and second sensing surfaces, the method comprising:

contacting the first and second sensing surfaces of a sensor of a device for multi-parametric testing of the intravenous fluid to the intravenous fluid;

determining a multi-parametric profile from the intravenous fluid, wherein the multi-parametric profile comprises

a first parameter detecting the fluid interactions at the first sensing surface, the first parameter comprising a complex admittance or impedance signal from the intravenous fluid, and

a second parameter detecting the fluid interactions at the second sensing surface, wherein the second parameter is independent of the first parameter;

comparing the multi-parametric profile to stored expected parameter values to determine an identity and a concentration of one or more components of the intravenous fluid.

2. The method of claim 1, wherein the step of comparing the multi-parametric profile comprises simultaneously identifying and determining the concentration of the one or more components of the intravenous fluid.

3. The method of claim 1, wherein the step of determining the multi-parametric profile comprises measuring an optical parameter.

4. The method of claim 1, wherein the first parameter comprises an electrical admittance or impedance measurement taken at a plurality of frequencies.

5. A method for determining an identity and a concentration of an intravenous fluid by detecting fluid interactions at first and second sensing surfaces, the method comprising:

contacting the intravenous fluid to the first and second sensing surfaces of a device for multi-parametric testing of the intravenous fluid;

determining a multi-parametric profile from the intravenous fluid, wherein the multi-parametric profile comprises

a first parameter detecting the fluid interactions at the first sensing surface, the first parameter comprises a first complex admittance or impedance signal from the intravenous fluid, and

a second parameter detecting the fluid interactions at the second sensing surface, wherein the second parameter comprises a second complex admittance or impedance signal from the intravenous fluid;

comparing the first and second parameters of the multi-parametric profile to stored expected parameter values to identify and determine a concentration of one or more components of the intravenous fluid.

6. The method of claim 5, wherein the first parameter comprises an admittance or impedance spectrum taken at a plurality of frequencies.

7. The method of claim 5, wherein the second parameter comprises an admittance or impedance spectrum taken at a plurality of frequencies.

8. The method of claim 5, wherein the step of determining the multi-parametric profile comprises determining a third parameter that is not a complex admittance or impedance signal.

9. The method of claim 8 wherein the third parameter is an optical parameter.

10. The method of claim 5, further comprising connecting the device for multi-parametric testing of the intravenous fluid to an intravenous infusion device for infusion of the fluid into a vascular system of a patient.

11. A method for determining an identity and a concentration of an intravenous fluid by detecting fluid interactions at first and second sensing surfaces, the method comprising:

applying the intravenous fluid to the first and second sensing surfaces of a device for testing of the intravenous fluid by admittance or impedance spectroscopy;

determining complex admittance or impedance signals from the intravenous fluid between a first pair of electrodes by detecting the fluid interactions at the first sensing surface;

determining complex admittance or impedance signals from the intravenous fluid between a second pair of electrodes by detecting the fluid interactions at the second sensing surface, and

comparing received parameter values incorporating the complex admittance or impedance signals with stored expected parameter values to identify and determine a concentration of one or more components of the intravenous fluid.

12. The method of claim 11, wherein the complex admittance or impedance signals comprise an admittance or impedance spectrum taken at a plurality of frequencies.

13. The method of claim 11, further comprising applying the intravenous fluid into a vascular system of a patient.

14. The method of claim 11, further comprising connecting the device to an intravenous infusion device for infusion of the fluid into a vascular system of a patient.