Flexible polymer microelectrode with fluid delivery capability and methods for making same

• US 9,014,796 B2
• Filed: 06/14/2006
• Issued: 04/21/2015
• Est. Priority Date: 06/14/2005
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Inventors: Kipke, Daryl R., Pellinen, David S.
• Primary Examiner(s): D'ANGELO, MICHAEL J
• Application Number:
  US11/452,551
• Publication Number:
  US 20060282014A1
• Time in Patent Office: 3,233 Days
• Field of Search: 600544-545
• US Class Current: 600/544
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition

Abstract

A flexible multi-modal microelectrode is provided that combines multi-channel fluidic and electrical interfaces for biological and other systems. Methods of making and using same are also disclosed.

Claims

1. A microelectrode device for receiving and sending electrical signals within a nervous system of a subject, said microelectrode device comprising:

a substantially-flexible planar shaft having a polymer-based substrate made of at least two flexible, planar thin-film polymer layers and at least one planar metallic layer, the substantially-flexible planar shaft having a proximal end and a distal end;

a plurality of electrode sites disposed on the shaft, at least one of the plurality of electrode sites operable to output a stimulating signal to the nervous system and at least one of the plurality of electrode sites operable to record an electrical signal within the nervous system;

at least one fluidic channel extending within the substantially-flexible planar shaft from the proximal end to generally the distal end, the at least one fluidic channel configured for the delivery of fluid to the nervous system,

a fluid delivery system fluidly coupled to the at least one fluidic channel, the fluid delivery system configured to output the fluid to the at least one fluidic channel;

a stimulating system operably coupled to the at least one of the plurality of electrode sites configured to output the stimulating signal; and

a recording system operably coupled to the at least one of the plurality of electrode sites configured to record the electrical signal within the nervous system;

wherein the outputting of the stimulating signal to the nervous system and the recording of the electrical signal within the nervous system are configured to occur simultaneously with the fluid being delivered to the nervous system.

2. The microelectrode device of claim 1, wherein the plurality of electrode sites and the at least one fluidic channel have respective connections compatible with the fluid delivery system, the stimulating system, and the recording system.

3. The microelectrode device of claim 1, wherein at least one of the plurality of electrode sites is disposed between the at least two flexible polymer layers.

4. The microelectrode device of claim 3, wherein the polymer-based substrate comprises at least five flexible thin-film polymer layers.

5. The microelectrode device of claim 1, wherein the at least one fluidic channel comprises a fluidic outlet and the substantially-flexible planar shaft further comprises a valve flap coupled to the fluidic outlet.

6. The microelectrode device of claim 5, wherein the valve flap is pressure-operated.

7. The microelectrode device of claim 1 wherein the fluid is a drug and the at least one fluidic channel is configured for the delivery of the drug to the nervous system.

8. The microelectrode device of claim 7 wherein the drug is delivered to the nervous system simultaneously with the outputting the stimulating signal to the nervous system, the recording electrical signal within the nervous system is responsive to affects caused by at least one of the delivery of the drug and the outputting the stimulating signal.

9. The microelectrode device of claim 1 wherein the at least one planar metallic layer is immediately adjacent to the at least one fluidic channel.

10. The microelectrode device of claim 1 wherein the at least one fluidic channel is further configured to extract fluid from the nervous system.

11. A method of using a microelectrode device for receiving and electrical signal sending electrical signals within a nervous system of a subject, the method comprising the steps of:

providing a substantially-flexible planar shaft having a polymer-based substrate made of at least two flexible, planar thin-film polymer layers and at least one planar metallic layer, the substantially-flexible planar shaft having a proximal end and a distal end;

providing a plurality of electrode sites disposed on the shaft, at least one of the plurality of electrode sites operable to output a stimulating signal to the nervous system and at least one of the plurality of electrode sites operable to record an electrical signal within the nervous system; and

providing at least one fluidic channel extending within the substantially-flexible planar shaft from the proximal end to generally the distal end, the at least one fluidic channel configured for the delivery of fluid to the nervous system; and

delivering the fluid to the nervous system simultaneously with outputting the stimulating signal to the nervous system and recording electrical signals within the nervous system.

12. The method in claim 11, wherein the at least one fluidic channel is configured to extract fluids from the nervous system.

13. The method of claim 11, wherein at least one of the plurality of electrode sites is disposed between the at least two flexible polymer layers.

14. The method of claim 11, wherein the polymer-based substrate comprises at least five flexible thin-film polymer layers.

15. The method of claim 11, wherein the at least one fluidic channel comprises a fluidic outlet and the substantially-flexible planar shaft further comprises a valve flap coupled to the fluidic outlet, the valve flap being actuated in response to pressure of the fluid.

16. The method of claim 11 wherein the step of delivering the fluid to the nervous system simultaneously with outputting the stimulating signal to the nervous system comprises delivering a drug to the nervous system simultaneously with outputting the stimulating signal to the nervous system;

and

recording electrical signals within the nervous system responsive to affects caused by the delivering the drug to the nervous system.

17. The method of claim 11 wherein the at least one planar metallic layer is immediately adjacent to the at least one fluidic channel.

18. A microelectrode device for receiving and sending electrical signals within a nervous system of a subject, said microelectrode device comprising:

a substantially-flexible planar shaft having a polymer-based substrate made of at least two flexible, planar thin-film polymer layers and at least one planar metallic layer, the substantially-flexible planar shaft having a proximal end and a distal end, the at least one planar metallic layer being positioned between the at least two flexible polymer layers and immediately adjacent the at least one fluidic channel;

a plurality of electrode sites disposed on the shaft, at least one of the plurality of electrode sites operable to output a stimulating signal to the nervous system and at least one of the plurality of electrode sites operable to record an electrical signal within the nervous system; and

at least one fluidic channel extending within the substantially-flexible planar shaft from the proximal end to generally the distal end, the at least one fluidic channel configured for the delivery of fluid to the nervous system,

a fluid delivery system fluidly coupled to the at least one fluidic channel, the fluid delivery system configured to output the fluid to the at least one fluidic channel;

a stimulating system operably coupled to the at least one of the plurality of electrode sites configured to output the stimulating signal; and

a recording system operably coupled to the at least one of the plurality of electrode sites configured to record the electrical signal within the nervous system;

wherein the outputting of the stimulating signal to the nervous system and the recording of the electrical signal within the nervous system are configured to occur simultaneously with the fluid being delivered to the nervous system.

19. The microelectrode device of claim 18, wherein at least one of the plurality of electrode sites is disposed between the at least two flexible polymer layers.

20. The microelectrode device of claim 18 wherein the fluid is a drug and the at least one fluidic channel is configured for the delivery of the drug to the nervous system.