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Transmucosal drug delivery device and method including electrically-actuated permeation enhancement

  • US 9,014,799 B2
  • Filed: 10/08/2009
  • Issued: 04/21/2015
  • Est. Priority Date: 10/08/2009
  • Status: Active Grant
First Claim
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1. An intravaginal device for transmucosal drug delivery comprising:

  • a housing shaped and dimensioned for intravaginal deployment and for holding the device in place in the vagina by frictional engagement between the housing and mucosal tissue of a human or animal subject;

    a drug-dispensing portion comprising a piston, an actuator, and a drug repository which contains at least one drug;

    an electrically-actuatable portion comprising a plurality of electrically-actuatable active disruption elements configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intravaginally deployed and retained in the human or animal subject; and

    a control module contained in the housing, the control module controlling the active disruption elements and the timing and sequence of the delivery of the drug from the drug repository by activation of the actuator and piston,wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.

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