Method and system for modulating neural activity in a limb
First Claim
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1. A method of modulating an immune or inflammatory response or process in a subject in need thereof, comprising:
- receiving a signal indicative of at least one of a first activity state and a second activity state of a subject;
delivering a blocking stimulus sufficient to produce a reversible conduction block in at least a portion of a sensory nerve of the subject, the blocking stimulus delivered in response to receipt of the signal indicative of at least one of the first activity state and the second activity state of the subject, wherein the blocking stimulus is delivered by a blocking stimulus source positioned substantially adjacent a skin surface in the vicinity of the sensory nerve; and
repeating delivery of the blocking stimulus in a cyclical application pattern, the cyclical application pattern including;
a blocking period during which the blocking stimulus is applied at least intermittently, the blocking period coinciding at least in part with the first activity state in the subject; and
a release period during which no blocking stimulus is applied, the release period coinciding at least in part with the second activity state in the subject.
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Abstract
Methods and related systems for modulating neural activity by cyclically blocking conduction in peripheral neural structures are disclosed. In an aspect, neural activity is blocked cyclically with a blocking stimulus source positioned adjacent a skin surface in a vicinity of a nerve. Neural modulation may be used, for example, to modulate an immune or inflammatory response or process.
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Citations
29 Claims
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1. A method of modulating an immune or inflammatory response or process in a subject in need thereof, comprising:
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receiving a signal indicative of at least one of a first activity state and a second activity state of a subject; delivering a blocking stimulus sufficient to produce a reversible conduction block in at least a portion of a sensory nerve of the subject, the blocking stimulus delivered in response to receipt of the signal indicative of at least one of the first activity state and the second activity state of the subject, wherein the blocking stimulus is delivered by a blocking stimulus source positioned substantially adjacent a skin surface in the vicinity of the sensory nerve; and repeating delivery of the blocking stimulus in a cyclical application pattern, the cyclical application pattern including; a blocking period during which the blocking stimulus is applied at least intermittently, the blocking period coinciding at least in part with the first activity state in the subject; and a release period during which no blocking stimulus is applied, the release period coinciding at least in part with the second activity state in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A neural modulation system, comprising:
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a package configured to be secured to a limb of a subject adjacent a skin surface in the vicinity of a sensory nerve; a signal input structure configured to receive a signal indicative of an activity state of the subject; a blocking stimulus source, the blocking stimulus source adapted to produce a blocking stimulus sufficient to reversibly block conduction in at least a portion of the sensory nerve; and a signal processing portion within the package, the signal processing portion including circuitry configured to; distinguish a first activity state of the subject from a second activity state of the subject based on the signal received at the signal input structure; and generate a blocking stimulus control signal for driving production of the blocking stimulus by the blocking stimulus source in a cyclical application pattern in response to at least one of the first activity state and the second activity state. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An article of manufacture, comprising:
one or more non-transitory, machine-readable, data storage media bearing one or more instructions relating to; receiving a signal indicative of at least one of a first activity state and a second activity state of a subject; delivering a blocking stimulus sufficient to produce a reversible conduction block in at least a portion of a sensory nerve of a subject, the blocking stimulus delivery in response to receipt of the signal indicative of at least one of the first activity state and the second activity state of the subject, wherein the blocking stimulus is delivered by a blocking stimulus source in a package secured to a limb of the subject adjacent a skin surface in the vicinity of the sensory nerve; and repeating delivery of the blocking stimulus in a cyclical application pattern under control of signal processing portion located in the package, the cyclical application pattern including; a blocking period during which the blocking stimulus is applied at least intermittently, the blocking period coinciding at least in part with the first activity state in the subject; and a release period during which no blocking stimulus is applied, the release period coinciding at least in part with the second activity state in the subject. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
Specification