Acquiring nerve activity from carotid body and/or sinus

• US 9,014,809 B2
• Filed: 10/30/2012
• Issued: 04/21/2015
• Est. Priority Date: 12/27/2007
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Farazi, Taraneh Ghaffari, Wenzel, Brian J.
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): Hankins, Lindsey G
• Application Number:
  US13/663,702
• Publication Number:
  US 20130060296A1
• Time in Patent Office: 903 Days
• Field of Search: 607/6, 607/9, 607/18, 607/22, 607/42, 607/44
• US Class Current: 607/42
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/388 Nerve conduction study, e.g. detecting action potential of peripheral nerves
• CPC Class Codes: A61B 5/4047 afferent nerves, i.e. nerves that relay impulses to the central nervous system
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

An exemplary embodiment includes acquiring an electroneurogram of the right carotid sinus nerve or the left carotid sinus nerve, analyzing the electroneurogram for at least one of chemosensory information and barosensory information and calling for one or more therapeutic actions based at least in part on the analyzing. Therapeutic actions may aim to treat conditions such as sleep apnea, an increase in metabolic demand, hypoglycemia, hypertension, renal failure, and congestive heart failure. Other exemplary methods, devices, systems, etc., are also disclosed.

Claims

1. A method comprising:

administering a treatment to a patient to cause at least one of a decrease or increase in the patient'"'"'s arterial oxygen concentration;

acquiring an electroneurogram indicative of at least a first carotid sinus nerve activity and changes therein that occur in response to the at least one of a decrease or increase in the patient'"'"'s arterial oxygen concentration that result from the administrating;

analyzing the electroneurogram to determine a relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity, wherein said analyzing includes determining how said first carotid sinus nerve activity changes in response to the at least one of a decrease or increase in the patient'"'"'s arterial oxygen saturation that results from the administrating; and

sensing a second carotid sinus nerve activity and using said second carotid sinus nerve activity and the determined relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity to control delivery of a therapy to treat at least one of a cardiopulmonary disorder or a respiratory disorder.

2. The method of claim 1 wherein the analyzing further comprises filtering the electroneurogram to determine chemosensory information.

3. The method of claim 2 wherein the chemosensory information comprises arterial oxygen concentration information.

4. The method of claim 1 wherein the analyzing further comprises filtering the electroneurogram to determine barosensory information.

5. One or more non-transitory computer-readable media comprising processor executable instructions thereon which, when executed by one or more processors, cause the one or more processors to perform a method comprising:

acquiring an electroneurogram indicative of at least a first carotid sinus nerve activity and changes therein that occur in response to at least one of a decrease or increase in a patient'"'"'s arterial oxygen concentration that result from administering a treatment to a patient to cause the at least one of the decrease or increase in the patient'"'"'s arterial oxygen concentration;

analyzing the electroneurogram to determine a relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity, wherein said analyzing includes determining how said first carotid sinus nerve activity changes in response to the at least one of a decrease or increase in the patient'"'"'s arterial oxygen saturation that results from the administrating; and

sensing a second carotid sinus nerve activity and using said second carotid sinus nerve activity and the determined relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity to control delivery of a therapy to treat at least one of a cardiopulmonary disorder or a respiratory disorder.

6. The one or more non-transitory computer-readable media of claim 5 wherein the analyzing further comprises filtering the electroneurogram to determine chemosensory information.

7. The one or more non-transitory computer-readable media of claim 6 wherein the chemosensory information comprises arterial oxygen concentration information.

8. The one or more non-transitory computer-readable media of claim 5 wherein the analyzing further comprises filtering the electroneurogram to determine barosensory information.

9. An implantable device comprising:

a lead including one or more electrodes configured to be positioned at or proximate to at least one of a right carotid sinus nerve or a left carotid sinus nerve to sense an electroneurogram signal indicative of carotid sinus nerve activity of at least one of the right carotid sinus nerve or the left carotid sinus nerve; and

a processor configured to

cause acquisition, using the lead, of an electroneurogram indicative of at least a first carotid sinus nerve activity and changes therein that occur in response to at least one of a decrease or increase in a patient'"'"'s arterial oxygen concentration that result from administering a treatment to a patient to cause the at least one of the decrease or increase in the patient'"'"'s arterial oxygen concentration;

analyze the electroneurogram to determine a relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity, wherein said analyzing includes determining how said first carotid sinus nerve activity changes in response to at least one of the decrease and/or increase in the patient'"'"'s arterial oxygen saturation that results from the administrating;

cause acquisition of a second carotid sinus nerve activity; and

use said second carotid sinus nerve activity and the determined relationship between said patient'"'"'s arterial oxygen concentration and said first carotid sinus nerve activity to control delivery of a therapy to treat at least one of a cardiopulmonary disorder or a respiratory disorder.

10. The implantable device of claim 9 wherein the processor is further configured to filter the electroneurogram to determine chemosensory information.

11. The implantable device of claim 10 wherein the chemosensory information comprises arterial oxygen concentration information.

12. The implantable device of claim 9 wherein the processor is further configured to filter the electroneurogram to determine barosensory information.