Transmucosal drug delivery device and method including microneedles
First Claim
Patent Images
1. An intravaginal device for transmucosal drug delivery comprising:
- a housing shaped and dimensioned for intravaginal deployment and for holding the device in place in the vagina by frictional engagement between the housing and mucosal tissue of a human or animal subject;
a drug-dispensing portion which contains at least one drug disposed in the housing;
a plurality of solid microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject; and
a control module comprising a power source and a controller, the controller being configured to actuate release of the at least one drug from the housing after the plurality of solid microneedles penetrate the mucosal barrier,wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of solid microneedles.
7 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.
-
Citations
25 Claims
-
1. An intravaginal device for transmucosal drug delivery comprising:
-
a housing shaped and dimensioned for intravaginal deployment and for holding the device in place in the vagina by frictional engagement between the housing and mucosal tissue of a human or animal subject; a drug-dispensing portion which contains at least one drug disposed in the housing; a plurality of solid microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject; and a control module comprising a power source and a controller, the controller being configured to actuate release of the at least one drug from the housing after the plurality of solid microneedles penetrate the mucosal barrier, wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of solid microneedles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A method for local transmucosal delivery of a drug to a human or animal subject comprising:
-
deploying a drug delivery device within a vagina of a human or animal subject, the drug delivery device comprising a housing shaped and dimensioned for intravaginal deployment and for holding the device in place in the vagina by frictional engagement between the housing and mucosal tissue, and a drug-dispensing portion contained within the housing; penetrating the mucosal tissue with a plurality of solid microneedles that extend from, or are extendable from, the housing at a selected time after the drug delivery device is deployed in the lumen; and dispensing a drug from the drug-dispensing portion through one or more openings in the housing to the region of the mucosal tissue that is disrupted by the microneedles. - View Dependent Claims (12, 13, 14, 15, 16, 17)
-
-
18. An intravaginal device for transmucosal drug delivery comprising:
-
a cylindrical housing shaped and dimensioned for intravaginal deployment and for holding the device in place in the vagina by frictional engagement between the housing and mucosal tissue of a human or animal subject, the housing having an elongated sidewall disposed between opposed ends; a plurality of microneedles extending from, or extendable from, the elongated sidewall of the housing, the microneedles being configured to penetrate a region of the mucosal barrier adjacent to the sidewall of the housing at a selected time after the device is intravaginally deployed in the human or animal subject, and a drug dispenser comprising a drug repository containing at least one drug and a positive displacement element adapted to dispense the at least one drug from the elongated sidewall of the housing through the plurality of microneedles or onto the region of the mucosal tissue disrupted by the microneedles. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25)
-
Specification