Calibrator for a sensor

• US 9,017,622 B2
• Filed: 11/27/2012
• Issued: 04/28/2015
• Est. Priority Date: 04/10/2012
• Status: Active Grant

• Current Assignee: Lightship Medical Limited
• Original Assignee: Lightship Medical Limited
• Inventors: Crane, Barry Colin, Paterson, William, Barwell, Nicholas Paul
• Primary Examiner(s): CONLEY, SEAN EVERETT
• Application Number:
  US13/686,534
• Publication Number:
  US 20130266478A1
• Time in Patent Office: 882 Days
• Field of Search: 422/22, 422/129, 422/430
• US Class Current: 422/430
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0228 using calibration standards
• CPC Class Codes: A61B 2562/242 Packaging, i.e. for packaging the sensor or apparatus before use
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61L 2/081 Gamma radiation
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps
• CPC Class Codes: B01J 19/00 Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• CPC Class Codes: G01N 2021/6484 Optical fibres
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 2021/775 Indicator and selective membrane
• CPC Class Codes: G01N 2021/7786 Fluorescence
• CPC Class Codes: G01N 21/278 Constitution of standards
• CPC Class Codes: G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing measuring or testing processes involving enzymes or microorganisms, compositions or test papers therefor; processes for forming such compositions, condition responsive control in microbiological or enzymological processes C12Q
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.

Claims

1. A calibrator for calibrating a sensor, comprising:

a calibration chamber for containing a calibration liquid, said liquid comprising water or an aqueous solution;

an H₂O₂-quenching material, exposed to an interior of the calibration chamber, for contacting the calibration liquid; and

a lead screw of a mechanism for changing the concentration of an analyte in the calibration liquid, and wherein the H₂O₂-quenching material is a coating on the lead screw.

2. A sensor kit comprising:

a sensor for detecting a saccharide, said sensor having a sensing region comprising a receptor for said saccharide; and

a calibrator including a sealed calibration chamber containing a calibration liquid and an H₂O₂-quenching material on an interior surface of the calibration chamber for contacting the calibration liquid, said liquid comprising water or an aqueous solution.

3. A sensor kit according to claim 2, wherein the sensor is a glucose sensor and the saccharide is glucose.