Methods of treating autoimmune disorders and/or inflammatory disorders
First Claim
1. A method for treating a subject having an autoimmune disorder and/or an inflammatory disorder comprising administering to said subject an effective amount of one or more dendrimers conjugated with one or more functional groups selected from the group consisting of a therapeutic agent, a targeting agent, a trigger agent, and an imaging agent,wherein said one or more dendrimers conjugated with one or more functional groups is represented by formula 1:
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Accused Products
Abstract
The present invention relates to dendrimer compositions configured for treating inflammatory disorders and autoimmune disorders, and related methods of synthesis. Specifically, the present invention relates to methods for treating rheumatoid arthritis with PAMAM dendrimers having functional ligands configured for treating rheumatoid arthritis (e.g., therapeutic agents, pro-drugs, targeting agents, trigger agents, imaging agents) (e.g., methotrexate).
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Citations
2 Claims
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1. A method for treating a subject having an autoimmune disorder and/or an inflammatory disorder comprising administering to said subject an effective amount of one or more dendrimers conjugated with one or more functional groups selected from the group consisting of a therapeutic agent, a targeting agent, a trigger agent, and an imaging agent,
wherein said one or more dendrimers conjugated with one or more functional groups is represented by formula 1:
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2. A composition comprising a dendrimer conjugated with one or more functional ligands as represented by formula 1:
Specification
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- Resources
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Current AssigneeBoard of Regents of the University of Michigan (University of Michigan)
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Original AssigneeBoard of Regents of the University of Michigan (University of Michigan)
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InventorsBaker, James R. Jr., Sternson, Larry A., Repp, David, Ladenheim, Deborah
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Primary Examiner(s)CANELLA, KAREN A
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Application NumberUS13/126,633Publication NumberTime in Patent Office1,996 DaysField of SearchNoneUS Class Current424/1.65CPC Class CodesA61K 47/551 one of the codrug's compone...A61K 47/56 the modifying agent being a...A61K 49/0043 Fluorescein, used in vivoA61K 49/085 conjugated systemsA61K 49/124 dendrimers, dendrons, hyper...A61P 19/02 for joint disorders, e.g. a...A61P 37/00 Drugs for immunological or ...
