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Method of treating rheumatoid arthritis using antibody to IL6R

  • US 9,017,678 B1
  • Filed: 08/12/2014
  • Issued: 04/28/2015
  • Est. Priority Date: 07/15/2014
  • Status: Active Grant
First Claim
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1. A method of treating or reducing the risk of rheumatoid arthritis in a human in need thereof, the method comprising administering to said human an antibody or antibody fragment that specifically binds an IL6R protein that comprises a mutation Asp358Ala or Val385Ile in SEQ ID NO:

  • 78;

    wherein the antibody or fragment comprises a VH domain derived from the recombination of a human VH segment, a human D gene segment and a human JH segment, the human VH segment encoding (i) a CDR1 comprising a Phe at position 4 shown in SEQ ID NO;

    109 and wherein said human comprises a VH gene segment encoding a CDR1 comprising a Phe at position 4 shown in SEQ ID NO;

    109, or the human expresses VH domains that comprise a CDR1 comprising a Phe at position 4 shown in SEQ ID NO;

    109;

    or (ii) a FW3 comprising a Thr at position 33 shown in SEQ ID NO;

    111 and wherein said human comprises a VH gene segment encoding a FW3 comprising a Thr at position 33 shown in SEQ ID NO;

    111 or the human expresses VH domains that comprise a FW3 comprising a Thr at position 33 shown in SEQ ID NO;

    111; and

    wherein said human comprises a nucleotide sequence encoding said IL6R protein comprising said Asp358Ala or Val385Ile in SEQ ID NO;

    78.

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