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Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists, and immunotoxins

  • US 9,017,679 B2
  • Filed: 04/27/2012
  • Issued: 04/28/2015
  • Est. Priority Date: 08/30/2005
  • Status: Active Grant
First Claim
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1. A method for enhancing expansion of antigen-specific CD8 T cells in a subject, the method comprising the steps of:

  • (a) administering to the subject (i) an antigenic composition comprising a cell expressing a cognate antigen of the antigen specific CD8 T cells, wherein the cognate antigen is a non-self antigen; and

    (ii) an immunostimulatory agent, wherein the immunostimulatory agent enhances the subject'"'"'s immune response to the antigenic composition; and

    wherein administration of (i) and (ii) is effective for inducing expansion of the antigen-specific CD8 T cells in the subject; and

    (b) administering to the subject an agonistic anti-TNFR25 antibody which specifically binds TNFR25 in an amount effective enhance the expansion of the antigen-specific CD8 T cells induced in step (a).

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