Multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration

• US 9,018,601 B2
• Filed: 01/28/2012
• Issued: 04/28/2015
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Balakin
• Inventors: Balakin, Vladimir
• Primary Examiner(s): MASKELL, MICHAEL P
• Application Number:
  US13/360,683
• Publication Number:
  US 20120143051A1
• Time in Patent Office: 1,186 Days
• Field of Search: 250/396.R, 250/396.ML, 2504921-4923, 313/62, 315/503, 315/504
• US Class Current: 250/492.3
• CPC Class Codes: A61N 2005/1059 using cameras imaging the patient
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: H05H 13/04 Synchrotrons

Abstract

The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Claims

1. A particle beam irradiation apparatus for cancer therapy of a tumor of a patient with charged particles running along a beam path, comprising:

a synchrotron, said synchrotron comprising at least a portion of said beam path, said synchrotron further comprising;

a center, wherein said beam path runs;

about said center;

through straight sections in said synchrotron; and

through turning sections in said synchrotron,

wherein each of said turning sections comprises a plurality of bending magnets,

wherein said circulation beam path comprises a length of less than sixty meters, and

wherein a number of said straight sections equals a number of said turning sections;

a respiration sensor generating a respiration signal, said respiration signal corresponding to a breathing cycle;

a rotatable platform,

wherein said beam path crosses above at least a portion of said rotatable platform,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period,

wherein said synchrotron comprises timing to a set point in said breathing cycle using said respiration signal,

wherein operation of said synchrotron at said set point of said breathing cycle occurs in greater than four rotation positions of said rotatable platform.

2. The apparatus of claim 1, wherein the charged particles irradiate the tumor of the patient.

3. The apparatus of claim 1, wherein said respiration sensor comprises a force meter strapped to the patient'"'"'s chest.

5. The apparatus of claim 1, further comprising:

a display screen displaying a breath control command to the patient.

6. The apparatus of claim 5, wherein said respiration signal is used in generating said breath control command and wherein said breath control command comprises a countdown to when the patient'"'"'s breath is to be held.

7. The apparatus of claim 1, wherein delivery of the charged particles at said set point of said breathing cycle occurs in greater than twenty rotation positions of said rotatable platform, wherein ingress energy of said charged particle beam is circumferentially distributed about the tumor.

8. The apparatus of claim 1, further comprising an X-ray source proximate said beam path, said X-ray source operable for imaging the tumor during delivery of the charged particles.

9. The apparatus of claim 1, wherein said synchrotron further comprises:

a radio-frequency cavity system comprising a first pair of blades for inducing betatron oscillation of the charged particles;

a foil yielding slowed charged particles from the charged particles having sufficient betatron oscillation to traverse said foil, wherein the slowed charged particles pass through a second pair of blades having an extraction voltage directing the charged particles out of said synchrotron through an extraction magnet.

10. The apparatus of claim 9, wherein said radio-frequency cavity system for inducing betatron oscillation is timed using said respiration signal.

11. The apparatus of claim 1, said synchrotron further comprising:

exactly four turning sections; and

no quadrupoles in the circulating path of the synchrotron.

12. The apparatus of claim 1, wherein said synchrotron further comprises:

exactly four ninety degree turning sections.

14. The apparatus of claim 1, further comprising:

a patient positioning system comprising an upper body support, wherein said upper body support comprises a semi-upright patient support surface, said semi-upright patient support surface supported by said rotatable platform,

wherein said beam path passes within about six inches of said semi-upright patient support surface.

15. The apparatus of claim 14, wherein said semi-upright patient support surface comprises an about vertical surface.

16. The apparatus of claim 14, wherein said semi-upright patient support surface comprises a reclined position from a vertical axis by less than about sixty-five degrees.

17. The apparatus of claim 14, wherein said patient positioning system further comprises at least three of:

a motorized torso positioning system;

a motorized head positioning system;

a motorized arm positioning system;

a motorized back positioning system; and

a motorized foot positioning system.

18. The apparatus of claim 17, further comprising computer memory for recalling individualized motor positions for any of:

said motorized torso positioning system;

said motorized head positioning system;

said motorized arm positioning system;

said motorized back positioning system; and

said motorized foot positioning system.

19. The apparatus of claim 14, wherein said charged particle irradiation system comprises control of:

beam energy; and

beam intensity.

20. The apparatus of claim 1, said particle beam irradiation apparatus further comprising:

a negative ion source, said negative ion source producing negative ions;

an ion beam focusing lens; and

a converting foil, said converting foil converting the negative ions into the charged particles.

21. The apparatus of claim 1, said particle beam irradiation apparatus further comprising:

an extraction material;

at least a one kilovolt direct current field applied across a pair of extraction blades; and

a deflector,

wherein the charged particles pass through said extraction material resulting in a reduced energy charged particle beam,

wherein the reduced energy charged particle beam passes between said pair of extraction blades, and

wherein the direct current field redirects the reduced energy charged particle beam through said deflector,

wherein said deflector yields an extracted charged particle beam.

4. A particle beam irradiation apparatus for cancer therapy of a tumor of a patient with charged particles running along a beam path, comprising:

a synchrotron, said synchrotron comprising at least a portion of said beam path;

a respiration sensor generating a respiration signal, said respiration signal corresponding to a breathing cycle; and

a rotatable platform,

wherein said beam path crosses above at least a portion of said rotatable platform,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period,

wherein said synchrotron comprises timing to a set point in said breathing cycle using said respiration signal,

wherein operation of said synchrotron at said set point of said breathing cycle occurs in greater than four rotation positions of said rotatable platform,

wherein said respiration sensor further comprises;

a first thermal resistor positioned proximate the patient'"'"'s nose;

a second thermal resistor positioned both out of an exhalation path of the patient and in the same local room environment as the rotatable platform,

wherein said respiration signal is generated using differences between readings from said first thermal resistor and said second thermal resistor.

13. A particle beam irradiation apparatus for cancer therapy of a tumor of a patient with charged particles running along a beam path, comprising:

a synchrotron, said synchrotron comprising at least a portion of said beam path;

a respiration sensor generating a respiration signal, said respiration signal corresponding to a breathing cycle;

a rotatable platform,

wherein said beam path crosses above at least a portion of said rotatable platform,

wherein said rotatable platform rotates through at least one hundred eighty degrees during an irradiation period,

wherein said synchrotron comprises timing to a set point in said breathing cycle using said respiration signal, and

wherein operation of said synchrotron at said set point of said breathing cycle occurs in greater than four rotation positions of said rotatable platform,

wherein said synchrotron further comprises exactly four ninety degree turning sections, wherein each of said four ninety degree turning sections further comprises at least four magnets having a total of at least eight beveled focusing edges.

22. A method for irradiation of a tumor of a patient with charged particles, comprising the steps of:

accelerating the charged particles with a synchrotron;

monitoring a breathing cycle with a respiration sensor, said respiration sensor generating a respiration signal corresponding to the patient'"'"'s breathing cycle;

rotating a platform holding the patient,

wherein said platform rotates through at least one hundred eighty degrees during an irradiation period of the patient,

using the respiration signal, delivering the charged particles to the tumor at a set point in the breathing cycle, wherein said step of delivering the charged particles at said set point of said breathing cycle occurs in greater than four rotation positions of said rotatable platform.

23. The method of claim 22, further comprising the steps of:

partially immobilizing the patient on a rotatable platform;

collecting a set of X-ray images of the patient, wherein at least thirty elements of said set comprises X-ray images with different rotation positions of said rotatable platform;

generating a multi-field image using said set of X-ray images;

developing an irradiation plan using said multi-field image; and

delivering the charged particles uses said irradiation plan.

24. The method of claim 22, wherein said step of monitoring further comprises the step of:

using a force meter strapped to the patient'"'"'s chest to generate said respiration signal.

25. The method of claim 22, wherein said step of monitoring further comprising the steps of:

sensing patient breathing with a first thermal resistor positioned proximate the patient'"'"'s nose; and

sensing room temperature using a second thermal resistor positioned both out of an exhalation path of the patient and in the same local room environment as the platform,

wherein said respiration signal is generated using differences between readings from said first thermal resistor and said second thermal resistor.

26. The method of claim 22, further comprising the steps of:

controlling an energy of the charged particle; and

controlling an intensity of the charged particles in greater than four rotation positions of said rotatable platform.

27. The method of claim 22, further comprising the steps of:

controlling a magnetic field in a bending magnet of said synchrotron, said bending magnet comprising;

a tapered iron based core adjacent a gap, said core comprising a surface polish of less than about ten microns roughness; and

a focusing geometry comprising;

a first cross-sectional distance of said iron based core forming an edge of said gap,

a second cross-sectional distance of said iron based core not in contact with said gap, wherein said second cross-sectional distance is at least fifty percent larger than said first cross-sectional distance, said first cross-sectional distance running parallel said second cross-sectional distance.

28. The method of claim 22, further comprising the steps of:

controlling an energy of the charged particle using an accelerator in said synchrotron, said accelerator comprising;

a set of at least ten coils;

a set of at least ten wire loops; and

a set of at least ten microcircuits, each of said microcircuits integrated to one of said loops, wherein each of said loops completes at least one turn about at least one of said coils; and

using a radio-frequency synthesizer, sending a low voltage signal to each of said microcircuits, each of said microcircuits amplifying said low voltage signal yielding an acceleration voltage.

29. The method of claim 22, further comprising the step of:

monitoring both a horizontal position of the charged particles and a vertical position of the charged particles using a coating on a foil, said coating comprising a layer yielding a localized photometric signal when struck by the charged particles.

30. The method of claim 22, further comprising the step of:

increasing an intensity of the charged particles when targeting a distal portion of the tumor, wherein said distal portion of said tumor changes with rotation of the patient on said platform, said platform rotating to as least ten distinct rotational positions in a period of less than one minute during irradiation of the tumor by the charged particles, said platform holding the patient.

31. The method of claim 22, further comprising the steps of:

horizontally controlling the charged particles;

vertically controlling the charged particles; and

providing an X-ray input signal, wherein said X-ray input signal comprises a signal generated by an X-ray source proximate the charged particles;

wherein both said step of horizontally controlling and said step of vertically controlling use said X-ray input signal.

32. The method of claim 22, further comprising the step of:

collecting multi-field X-ray images of the tumor using an X-ray generation source located within about forty millimeters of the charged particle beam path, wherein said X-ray source maintains a single static position;

(1) during use of said X-ray source and (2) during tumor treatment with the charged particles,

wherein X-rays emitted from said X-ray source run substantially in parallel with the charged particles.