Surgical assistance planning method using lung motion analysis
First Claim
1. A medical method for observing the local motion of a medical implement in a lung of a subject comprising the steps of:
- a) receiving first image data that includes a lung tissue of the lung in a first state;
b) receiving second image data that includes the lung tissue of the lung in a second state different than the first state;
c) rigidly registering the first image data and the second image data with one another using an anatomical reference wherein the anatomical reference excludes the lung tissue and is a relatively fixed anatomical structure having minimal deflection between breathing states of the lung;
d) based on the anatomical reference from the rigidly registering step, deforming at least one of the following;
i) the first image data of the lung to match the second image data of the lung, and ii) the second image data of the lung to match the first image data of the lung by moving voxels in at least one of the first image data or the second image data until voxel intensity values of the first and second image data are matched; and
e) generating a motion vector field of the magnitude and direction of local motion of the lung tissue based on the rigidly registering step and deforming step wherein the local motion of the lung tissue between first and second states is independent of the anatomical reference defined in the rigidly registering step.
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Abstract
A medical analysis method for estimating a motion vector field of the magnitude and direction of local motion of lung tissue of a subject is described. In one embodiment a first 3D image data set of the lung and a second 3D image data set is obtained. The first and second 3D image data sets correspond to images obtained during inspiration and expiration respectively. A rigid registration is performed to align the 3D image data sets with one another. A deformable registration is performed to match the 3D image data sets with one another. A motion vector field of the magnitude and direction of local motion of lung tissue is estimated based on the deforming step. The motion vector field may be computed prior to treatment to assist with planning a treatment as well as subsequent to a treatment to gauge efficacy of a treatment. Results may be displayed to highlight.
25 Citations
34 Claims
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1. A medical method for observing the local motion of a medical implement in a lung of a subject comprising the steps of:
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a) receiving first image data that includes a lung tissue of the lung in a first state; b) receiving second image data that includes the lung tissue of the lung in a second state different than the first state; c) rigidly registering the first image data and the second image data with one another using an anatomical reference wherein the anatomical reference excludes the lung tissue and is a relatively fixed anatomical structure having minimal deflection between breathing states of the lung; d) based on the anatomical reference from the rigidly registering step, deforming at least one of the following;
i) the first image data of the lung to match the second image data of the lung, and ii) the second image data of the lung to match the first image data of the lung by moving voxels in at least one of the first image data or the second image data until voxel intensity values of the first and second image data are matched; ande) generating a motion vector field of the magnitude and direction of local motion of the lung tissue based on the rigidly registering step and deforming step wherein the local motion of the lung tissue between first and second states is independent of the anatomical reference defined in the rigidly registering step. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 33, 34)
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11. A medical method for observing the efficacy of a region in the lung of a subject comprising the steps of:
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a) receiving first image data of the lung in a first state; b) receiving second image data of the lung in a second state; c) registering the first image data and the second image data with one another using a plurality of types of anatomical reference features and wherein each of the anatomical reference features exclude the lung tissue and have minimal deflection between the first and second states; d) deforming at least one of the following;
i) the first image data of the lung to match the second image data of the lung, and ii) the second image data of the lung to match the first image data of the lung; ande) generating a first motion vector field of the magnitude and direction of local motion of lung tissue based on the deforming step wherein the local motion of the lung tissue between first and second states is independent of the anatomical references defined in the rigidly registering step. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A medical analysis method for estimating a motion vector field of the magnitude and direction of local motion of lung tissue of a subject comprising the steps of:
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a) receiving first image data of the lung in a first state; b) receiving second image data of the lung in a second state; c) identifying an anatomical reference wherein the anatomical reference is a fixed anatomical structure and excludes lung tissue; d) registering the first image data and the second image data with one another using the fixed anatomical reference; d) deforming at least one of the following;
i) the first image data of the lung to match the second image data of the lung, and ii) the second image data of the lung to match the first image data of the lung; ande) estimating a motion vector field of the magnitude and direction of local motion of lung tissue based on the deforming step wherein the local motion of the lung tissue between first and second states is relative to an anatomical reference defined in the rigidly registering step. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A medical analysis method for estimating a motion vector field of the magnitude and direction of local motion of lung tissue of a first subject comprising the steps of:
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a) receiving first image data of the lung of the first subject in a first state; b) generating an atlas motion vector field, wherein the step of generating the atlas motion vector field comprises; receiving first image data of the lung of a second subject in a first state; receiving second image data of the lung of the second subject in a second state; registering the first image data of the second subject and the second image data of the second subject with one another using a reference feature; deforming at least one of the following;
i) the first image data of the second subject to match the second image data of the second subject, and ii) the second image data of the second subject to match the first image data of the second subject; andestimating the atlas motion vector field based on the deforming step; and c) estimating the local motion of the lung of the first subject based on the atlas motion vector field. - View Dependent Claims (32)
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Specification