Combination therapy including peripheral nerve field stimulation

• US 9,020,599 B2
• Filed: 12/17/2013
• Issued: 04/28/2015
• Est. Priority Date: 06/09/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rooney, Ethan A., Wahlstrand, Carl D., King, Gary W., Cross, Thomas E. Jr., Heruth, Kenneth T., Wacnik, Paul W., Evanson, Jeffrey S.
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US14/109,049
• Publication Number:
  US 20140107747A1
• Time in Patent Office: 497 Days
• Field of Search: 607/46
• US Class Current: 607/46
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings

Abstract

Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

Claims

1. A method for treating pain of a patient, the method comprising:

delivering peripheral nerve field stimulation to a region of a body of the patient in which a patient experiences pain via at least one electrode implanted in the region; and

delivering at least one other therapy that treats pain to the patient in combination with the peripheral nerve field stimulation.

2. The method of claim 1, wherein delivering peripheral nerve field stimulation via at least one electrode implanted in the region comprises delivering peripheral nerve field stimulation via at least one electrode implanted within or between at least one of an intra-dermal, deep dermal, or subcutaneous layer of the region.

3. The method of claim 1, wherein delivering peripheral nerve field stimulation and at least one other therapy comprises delivering the peripheral nerve field stimulation and the other therapy from a single implantable medical device.

4. The method of claim 1, wherein delivering peripheral nerve field stimulation and at least one other therapy comprises delivering the peripheral nerve field stimulation and the other therapy to different locations of the body of the patient.

5. The method of claim 1, wherein delivering peripheral nerve field stimulation and at least one other therapy comprises delivering the peripheral nerve field stimulation and the other therapy simultaneously.

6. The method of claim 1, wherein delivering peripheral nerve field stimulation and at least one other therapy comprises alternating delivery of the peripheral nerve field stimulation and the other therapy.

7. The method of claim 1, wherein delivering at least one other therapy in combination with the peripheral nerve field stimulation comprises delivering another neurostimulation therapy to a different location within the patient via a respective one or more electrodes.

8. The method of claim 7, wherein delivering the another neurostimulation therapy in combination with the peripheral nerve field stimulation comprises delivering the other neurostimulation therapy and the peripheral nerve field stimulation according to at least one of different stimulation parameters or different duty cycles.

9. The method of claim 7, wherein delivering the another neurostimulation therapy in combination with the peripheral nerve field stimulation comprises:

delivering the other neurostimulation therapy and the peripheral nerve field stimulation according to different programs within a group that includes a plurality of programs; and

delivering each successive stimulation pulse from an implantable medical device according to a different one of the programs.

10. The method of claim 7, wherein delivering peripheral nerve field stimulation to a region of a body of the patient in which a patient experiences pain comprises delivering peripheral nerve field stimulation to an axial region of a back of the patient.

11. The method of claim 7, wherein delivering another neurostimulation therapy comprises delivering at least one of peripheral nerve stimulation, deep brain stimulation, or cortical stimulation in combination with the peripheral nerve field stimulation.

12. The method of claim 1, wherein delivering at least one other therapy in combination with the peripheral nerve field stimulation comprises delivering at least one therapeutic agent in combination with the peripheral nerve field stimulation.

13. The method of claim 12, wherein delivering at least one therapeutic agent comprises delivering at least one of an opioid, cannabinoid, local anesthetic, baclofen, adenosine, alpha blocker, anti-inflammatory, steroid, muscle relaxant, antidepressant, or antiepileptic.

14. A system for treating pain of a patient, the system comprising:

a therapy delivery module configured to deliver a therapy to the patient; and

a processor configured to control the delivery of the therapy to the patient via the therapy module, wherein the therapy includes delivery of peripheral nerve field stimulation to a region of a body of the patient in which the patient experiences pain via at least one electrode implanted in the region, and delivery of at least one other therapy that treats pain to the patient in combination with the peripheral nerve field stimulation.

15. The system of claim 14, wherein the processor is configured to control delivery of the peripheral nerve field stimulation via the at least one electrode implanted within or between at least one of an intra-dermal, deep dermal, or subcutaneous layer of the region.

16. The system of claim 14, wherein the processor is configured to control delivery of the peripheral nerve field stimulation and the other therapy from a single implantable medical device.

17. The system of claim 14, wherein the processor is configured to control delivery of the peripheral nerve field stimulation and the other therapy to different locations of the body of the patient.

18. The system of claim 14, wherein the processor is configured to control delivery of the peripheral nerve field stimulation and the other therapy simultaneously.

19. The system of claim 14, wherein the processor is configured to control delivery of the therapy by at least alternating delivery of the peripheral nerve field stimulation and the other therapy.

20. The system of claim 14, wherein the processor is configured to control delivery of the another neurostimulation therapy to a different location within the patient via a respective one or more electrodes.

21. The system of claim 20, wherein the processor is configured to control delivery of the other neurostimulation therapy and the peripheral nerve field stimulation according to at least one of different stimulation parameters or different duty cycles.

22. The system of claim 20, wherein the processor is configured to control delivery of the other neurostimulation therapy and the peripheral nerve field stimulation according to different programs within a group that includes a plurality of programs, and to control delivery of each successive stimulation pulse from an implantable medical device according to a different one of the programs.

23. The system of claim 20, wherein the processor is configured to control delivery of the peripheral nerve field stimulation to an axial region of a back of the patient.

24. The system of claim 20, wherein the processor is configured to control delivery of at least one of peripheral nerve stimulation, deep brain stimulation, or cortical stimulation in combination with the peripheral nerve field stimulation.

25. The system of claim 14, wherein the processor is configured to control delivery of at least one therapeutic agent in combination with the peripheral nerve field stimulation.

26. The system of claim 25, wherein the processor is configured to control delivery of at least one of an opioid, cannabinoid, local anesthetic, baclofen, adenosine, alpha blocker, anti-inflammatory, steroid, muscle relaxant, antidepressant, or antiepileptic.