Implantable multi-electrode device

• US 9,020,607 B2
• Filed: 06/26/2014
• Issued: 04/28/2015
• Est. Priority Date: 07/21/2005
• Status: Active Grant

• Current Assignee: Medtronic Bakken Research Center B.V. (Medtronic Plc)
• Original Assignee: Sapiens Steering Brain Stimulation B.V. (Medtronic Plc)
• Inventors: Merz, Matthias, Ponomarev, Youri V., Pijnenburg, Remco H.W.
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): FAIRCHILD, MALLIKA DIPAYAN
• Application Number:
  US14/315,869
• Publication Number:
  US 20140309548A1
• Time in Patent Office: 306 Days
• Field of Search: 607/45, 607/48, 607/116, 607/120, 607128-130, 607/108
• US Class Current: 607/116
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0536 Preventing neurodegenerative response or inflammatory reaction
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

The invention provides an implantable multi-electrode device (300) and related methods and apparatuses. In one embodiment, the invention includes an implantable device (300) comprising: an assembly block (320); and a plurality of leads (340 . . . 348) radiating from the assembly block (320), each of the plurality of leads (340 . . . 348) containing at least one electrode (342A), such that the electrodes are distributed within a three-dimensional space, wherein the assembly block (320) includes a barb (350) for anchoring the assembly block (320) within implanted tissue.

Claims

1. A method for delivering an electrical stimulus to an individual, the method comprising administering the electrical stimulus to a tissue of the individual via an implantable medical device, the implantable medical device comprising:

an assembly block; and

a plurality of leads extending from the assembly block, wherein each of the plurality of leads includes at least one electrode, wherein the plurality of leads are configured such that the at least one electrode of each of the plurality of leads are distributed within a three-dimensional tissue space, wherein the assembly block and the plurality of leads are contained within a biodegradable encapsulant during implantation of the implantable medical device such that the at least one electrode of each of the plurality of leads assume a first distribution within the biodegradable encapsulant, and wherein the at least one electrode of each of the plurality of leads are configured to assume a second distribution upon degradation of the biodegradable encapsulant.

2. The method of claim 1, wherein the assembly block includes at least one barb for anchoring the assembly block within the tissue.

3. The method of claim 2, wherein the at least one barb is configured to be retracted toward the assembly block in a first position and extend from the assembly block in a second position.

4. The method of claim 1, wherein at least one of the plurality of leads includes more than one electrode.

5. The method of claim 1, wherein the biodegradable encapsulant is configured to protect the implantable medical device during implantation.

6. The method of claim 5, wherein the encapsulant includes at least one of the following:

polylactic acid (PLA), polyglycolic acid (PGA), polydioxanone (PDS), polyethylene glycol (PEG), and polyhydroxy butyrate (PHB).

7. The method of claim 1, wherein the plurality of leads are prearranged such that the distribution of the electrodes corresponds to targeted volume of the tissue.

8. The method of claim 1, wherein administering includes administering the electrical stimulus to a volume of the tissue smaller than a maximum volume possible by using fewer electrodes than are contained within the plurality of leads.

9. The method of claim 1, further comprising

recording neural activity within the three-dimensional tissue space using at least one of the electrodes.

10. The method of claim 1, wherein the electrical stimulus is configured to reduce a tremor suffered by the individual.

11. The method of claim 10, further comprising

administering to the individual at least one anti-tremor medication.

12. The method of claim 1, wherein the individual is suffering from at least one of the following:

Parkinson'"'"'s Disease, depression, a bipolar disorder, an obsessive convulsive disorder and epilepsy.

13. The method of claim 1, further comprising implanting an implantable medical device in the patient.

14. The method claim 1, wherein the encapsulant includes an anti-inflammatory compound configured to be released while the encapsulant degrades.