Systems and methods for determining volume of activation for deep brain stimulation
First Claim
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1. A computer system comprising:
- a processor configured to execute;
a finite element model (FEM) module to determine a FEM that models an implanted electrode and a tissue medium in which the electrode is implanted;
a Fourier FEM solver module to calculate a potential distribution in the tissue medium using information from the FEM module and a capacitive component of at least one of the electrode and the tissue medium; and
a volume of activation (VOA) module to provide a predicted VOA using the potential distribution and a neuron model.
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Abstract
This document discusses, among other things, systems and methods for determining volume of activation for deep brain stimulation (“DBS”) using a finite element model (FEM) circuit to determine a FEM of an implanted electrode and a tissue medium in which the electrode is implanted, a Fourier FEM solver circuit to calculate a potential distribution in the tissue medium using information from the FEM circuit and a capacitive component of at least one of the implanted electrode and the tissue medium, and a volume of activation (VOA) circuit to predict a VOA using the potential distribution and a neuron model.
145 Citations
24 Claims
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1. A computer system comprising:
a processor configured to execute; a finite element model (FEM) module to determine a FEM that models an implanted electrode and a tissue medium in which the electrode is implanted; a Fourier FEM solver module to calculate a potential distribution in the tissue medium using information from the FEM module and a capacitive component of at least one of the electrode and the tissue medium; and a volume of activation (VOA) module to provide a predicted VOA using the potential distribution and a neuron model. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A computer system comprising:
a processor configured to execute; a finite element model (FEM) module to determine a FEM that models an implanted electrode, a tissue medium in which the electrode is implanted, and an electrode-tissue interface; a Fourier FEM solver module to calculate a potential distribution in the tissue medium using information from the FEM module and a capacitive component of at least one of the electrode, the tissue medium, and the electrode-tissue interface; and a volume of activation (VOA) module to provide a predicted VOA using the potential distribution and a neuron model. - View Dependent Claims (9, 10)
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11. A non-transitory computer-readable storage medium, having stored thereon instructions executable by a processor, the instructions which, when executed by the processor, cause the processor to perform a method, the method comprising:
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determining a finite element model (FEM) of an implanted electrode and a tissue medium in which the electrode is implanted; calculating a potential distribution in the tissue medium using a Fourier FEM solver and a capacitive component of at least one of the electrode and the tissue medium; and predicting a volume of activation (VOA) using the potential distribution and a neuron model.
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12. A computer system comprising:
hardware means for; determining a finite element model (FEM) of an implanted electrode and a tissue medium in which the electrode is implanted; calculating a potential distribution in the tissue medium using a Fourier FEM solver and a capacitive component of at least one of the electrode and the tissue medium; and predicting a volume of activation (VOA) using the potential distribution and a neuron model.
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13. A computer-implemented method comprising:
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determining, by a computer processor, a finite element model (FEM) of an implanted electrode and a tissue medium in which the electrode is implanted; calculating, by the processor, a potential distribution in the tissue medium using a Fourier FEM solver and a capacitive component of at least one of the electrode and the tissue medium; and predicting, by the processor, a volume of activation (VOA) using the potential distribution and a neuron model. - View Dependent Claims (14, 15, 16, 17, 18, 19)
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20. A computer-implemented method comprising:
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determining, by a computer processor, a finite element model (FEM) of an implanted electrode, a tissue medium in which the electrode is implanted, and an electrode-tissue interface; calculating, by the processor, a potential distribution in the tissue medium using a Fourier FEM solver and a capacitive component of at least one of the electrode, the tissue medium, and the electrode-tissue interface; and predicting, by the processor, a volume of activation (VOA) using the potential distribution and a neuron model. - View Dependent Claims (21, 22)
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23. A computer system comprising:
a processor configured to execute; a finite element model (FEM) module to determine a FEM that models an implanted electrode and a tissue medium in which the electrode is implanted; a Fourier FEM solver module to calculate a potential distribution in the tissue medium using information from the FEM circuit and a capacitive component of the electrode and not of the tissue medium; and a volume of activation (VOA) module to provide a predicted VOA using the potential distribution and a neuron model.
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24. A computer system comprising:
a processor configured to execute; a finite element model (FEM) module to determine a FEM that models an implanted electrode and a tissue medium in which the electrode is implanted; a Fourier FEM solver module to calculate a potential distribution in the tissue medium using information from the FEM circuit and a capacitive component of the tissue medium and not the electrode; and a volume of activation (VOA) module to provide a predicted VOA using the potential distribution and a neuron.
Specification