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Method and apparatus for measuring glucose in body fluids using sub-dermal body tissue impedance measurements

  • US 9,022,932 B2
  • Filed: 02/04/2005
  • Issued: 05/05/2015
  • Est. Priority Date: 02/05/2004
  • Status: Active Grant
First Claim
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1. An apparatus implantable in the sub-dermal tissue body tissue of a subject for measuring or monitoring blood glucose level in the subject, the apparatus being adapted to measure impedance of the body tissue of the subject resulting from an electrical current flowing through said body tissue and to determine a blood glucose level of said subject based on the measured impedance, wherein the body tissue is sub-dermal or subcutaneous tissue of said subject, and wherein the apparatus is a four-point apparatus that comprises:

  • one pair of injection electrodes adapted for injection of the electrical current into the body tissue, wherein the electrical current is passed from one of the injection electrodes to the other of the injection electrodes through the body;

    one pair of sensing electrodes adapted to detect the resulting voltage caused by the current flowing between the pair of injection electrodes and through said body tissue;

    a device for measuring impedance of the body tissue, said device being operatively connected to the pair of sensing electrodes and adapted to receive the voltage detected by the sensing electrodes, wherein the impedance of the body tissue is measured based on the voltage detected by the pair of sensing electrodes;

    a microprocessor operatively connected to the device for measuring impedance and being programmed to determine the blood glucose level in the subject by correlating the measured impedance with a predetermined relationship between impedance and glucose levels, andwherein the injection electrodes, the sensing electrodes, the device for measuring impedance and the microprocessor are contained in a housing allowing for implantation sub-dermally;

    and wherein the electrical current is an alternating, AC, current having a frequency of less than 10 MHz.

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