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Methods and systems that monitor for an impending myocardial infarction

  • US 9,022,945 B2
  • Filed: 02/04/2014
  • Issued: 05/05/2015
  • Est. Priority Date: 07/08/2009
  • Status: Active Grant
First Claim
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1. For use with a chronically implanted device, a method for monitoring for an impending myocardial infarction (MI), comprising:

  • (a) obtaininga first signal indicative of changes arterial volume, the first signal comprising one of a photoplethysmography (PPG) signal or an impedance-plethysmography (IPG) signal, anda second signal indicative of electrical cardiac activity, the second signal comprising one of an electrocardiogram (ECG) signal or an intracardiac electrogram (IEGM) signal;

    (b) determining, based on the first and second signals, a metric indicative of aortic pulse wave velocity (PWV);

    (c) determining, based on the first signal, a metric indicative of diastolic blood pressure (DBP);

    (d) determining, based on at least one of the first and or second signals, a metric indicative of heart rate (HR);

    (e) determining, based on the first signal, a metric indicative of vascular stiffness (VS) by determining a measure of a number of inflections in the first signal, wherein a greater the measure of the number of inflections in the first signal a greater the vascular stiffness;

    (f) monitoring for an impending MI based on the metrics indicative of PWV, DBP, HR and VS, wherein an increase in each of the metrics indicative of PWV, DBP, HR and VS is interpreted as an increase in a risk of an impending MI; and

    (g) triggering an alert and/or therapy in response to an impending MI being detected at step (f);

    wherein one or more of steps (b) through (g) is/are performed using a processor.

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