Renal ablation electrode with force-activatable conduction apparatus

• US 9,023,034 B2
• Filed: 11/22/2011
• Issued: 05/05/2015
• Est. Priority Date: 11/22/2010
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Jenson, Mark L., Smith, Scott, Sogard, David
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US13/303,130
• Publication Number:
  US 20120172870A1
• Time in Patent Office: 1,260 Days
• Field of Search: None
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2018/00029 open
• CPC Class Codes: A61B 2018/00404 Blood vessels other than those in or around the heart
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2018/00511 Kidney
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/1465 Deformable electrodes
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure

Abstract

An electrode is provided at a distal end of a catheter and dimensioned for deployment within a renal artery. A deformable cover of the electrode incorporates a force-activatable conduction apparatus. The cover is configured to conduct electrical energy only through a region or regions of the cover subject to deformation due to contact with a wall of the target vessel. The electrical energy is sufficient to ablate perivascular renal nerves proximate the deformed region or regions of the electrode cover. The cover is configured to prevent conduction of electrical energy through the cover in the absence of a deformation force applied to the cover.

Claims

1. An apparatus, comprising:

a catheter comprising a flexible shaft having a proximal end, a distal end, and a length sufficient to access a patient'"'"'s renal artery relative to a percutaneous access location;

a conductor arrangement extending along the shaft between the proximal and distal ends of the shaft;

an electrode provided at the distal end of the shaft, coupled to the conductor arrangement, and dimensioned for deployment within the renal artery; and

a deformable cover provided at the electrode and comprising a force-activatable conduction apparatus, the cover configured to prevent conduction of electrical energy through the cover in the absence of cover deformation, and to conduct electrical energy only through a region or regions of the cover subject to deformation, the electrical energy sufficient to ablate perivascular renal nerves proximate the deformed region or regions of the cover.

2. The apparatus of claim 1, wherein:

the force-activatable conduction apparatus comprises a plurality of segments distributed on the deformable cover;

each of the segments comprises semiconductor material and insulating material arranged relative to electroactive material to define a force-activated solid-state switching structure; and

the electroactive material of each segment generates a voltage that causes conduction of electrical energy from the electrode, through the segment, and to the perivascular renal nerves proximate the segment when the electroactive layer is force-activated.

3. The apparatus of claim 1, wherein:

the force-activatable conduction apparatus comprises a plurality of segments distributed on the deformable cover;

each of the segments comprises semiconductor material and insulating material arranged relative to an electroactive layer to define an inner collector layer electrically coupled to the electrode, an outer emitter layer, and a base layer electrically coupled to the electroactive layer;

the electroactive layer is configured to generate a voltage that is communicated to the base layer in response to a mechanical force transferred to the electroactive layer; and

the base layer of each segment is configured to cause current to flow from the electrode, through the segment, and to the perivascular renal nerves proximate the segment when the electroactive layer is force-activated.

4. The apparatus of claim 1, wherein:

the force-activatable conduction apparatus comprises a plurality of conductive particles distributed within a nonconductive matrix and in a non-contacting relationship in the absence of cover deformation; and

deformation of a region of the cover causes displacement of the nonconductive matrix from a set of conductive particles proximate the deformed cover region, allowing the set of conductive particles to contact one another and conduct electrical energy from the electrode, through the deformed cover region, and into the perivascular renal nerves proximate the deformed cover region.

5. The apparatus of claim 4, wherein the nonconductive matrix comprises a silicone gel.

6. The apparatus of claim 1, wherein the force-activatable conduction apparatus comprises:

an inner conductive layer;

an outer conductive layer defining a plurality of electrically isolated segments; and

a displaceable insulating layer disposed between the inner and outer conductive layers.

7. The apparatus of claim 6, wherein the outer conductive layer comprises a grid of conductive material each surrounded by non-conductive material, the grid of isolated conductive material defining the plurality of electrically isolated segments.

8. The apparatus of claim 6, wherein the displaceable insulating layer comprises an electrically insulating gel.

9. The apparatus of claim 6, wherein deformation of a region of the cover causes displacement of the insulating layer from one or more of the electrically isolated segments proximate the deformed cover region, allowing conduction of electrical energy from the electrode, through the one or more of the electrically isolated segments proximate the deformed cover region, and into the perivascular renal nerves proximate the deformed cover region.

10. The apparatus of claim 1, wherein the cover comprises a deformable shell having an inner surface and an outer surface, the inner surface of the deformable shell arranged in a non-contacting relationship with the electrode in the absence of cover deformation and comprising:

a plurality of conductive elements extending from the inner surface to the outer surface of the shell; and

an insulating material disposed between adjacent ones of the plurality of conductive elements.

11. The apparatus of claim 10, wherein:

deformation of a region of the shell causes conductive elements of the plurality of conductive elements proximate the deformed shell region to contact the electrode, allowing conduction of electrical energy from the electrode, through conductive elements of the deformed shell region, and into the perivascular renal nerves proximate the deformed shell region.

12. An apparatus, comprising:

a catheter comprising a flexible shaft having a proximal end, a distal end, and a length sufficient to access a target vessel of the body relative to a percutaneous access location;

a conductor arrangement extending along the shaft between the proximal and distal ends of the shaft;

an electrode provided at the distal end of the shaft, coupled to the conductor arrangement, and dimensioned for deployment within the target vessel; and

a deformable cover provided at the electrode and comprising a force-activatable conduction apparatus, the cover configured to prevent conduction of electrical energy through the cover in the absence of cover deformation, and to conduct electrical energy only through a region or regions of the cover subject to deformation, the electrical energy sufficient to ablate target tissue proximate the deformed region or regions of the cover.

13. The apparatus of claim 12, wherein:

the force-activatable conduction apparatus comprises a plurality of segments distributed on the deformable cover;

each of the segments comprising semiconductor material and insulating material arranged relative to electroactive material to define a force-activated solid-state switching structure; and

the electroactive material of each segment generating a voltage that facilitates conduction of electrical energy from the electrode, through the segment, and to the target tissue proximate the segment when the electroactive layer is force-activated.

14. The apparatus of claim 13, wherein deformation of a region of the cover causes displacement of the insulating layer from one or more of the electrically isolated segments proximate the deformed cover region, allowing conduction of electrical energy from the electrode, through the one or more of the electrically isolated segments proximate the deformed cover region, and into the target tissue proximate the deformed cover region.

15. The apparatus of claim 12, wherein:

the force-activatable conduction apparatus comprises a plurality of conductive particles distributed within a nonconductive matrix and in a non-contacting relationship in the absence of cover deformation; and

deformation of a region of the cover causes displacement of the nonconductive matrix from a set of conductive particles proximate the deformed cover region, allowing the set of conductive particles to contact one another and conduct electrical energy from the electrode, through the deformed cover region, and into the target tissue proximate the deformed cover region.

16. The apparatus of claim 12, wherein the force-activatable conduction apparatus comprises:

an inner conductive layer;

an outer conductive layer defining a plurality of electrically isolated segments; and

a displaceable insulating layer disposed between the inner and outer conductive layers.

17. The apparatus of claim 12, wherein the cover comprises a deformable shell having an inner surface and an outer surface, the inner surface of the deformable shell arranged in a non-contacting relationship with the electrode in the absence of cover deformation and comprising:

a plurality of conductive elements extending from the inner surface to the outer surface of the shell; and

an insulating material disposed between adjacent ones of the plurality of conductive elements.

18. The apparatus of claim 17, wherein:

deformation of a region of the shell causes conductive elements of the plurality of conductive elements proximate the deformed shell region to contact the electrode, allowing conduction of electrical energy from the electrode, through conductive elements of the deformed shell region, and into the target tissue proximate the deformed shell region.

19. A method, comprising:

situating an electrode comprising a deformable cover within a target vessel;

deforming one or more regions of the cover in response to forcing the cover against a wall of the target vessel;

conducting ablative electrical energy only through the one or more deformed cover regions and into target tissue proximate the one or more deformed cover regions; and

preventing conduction of ablative electrical energy through the cover in the absence of cover deformation.

20. The method of claim 19, wherein the target vessel comprises a renal artery, and the target tissue comprises perivascular renal nerves.