Drug releasing coatings for medical devices
First Claim
1. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising a coating layer overlying an exterior surface of the medical device, the coating layer comprising a therapeutic agent and an additive, wherein:
- the therapeutic agent is chosen from paclitaxel, rapamycin, and mixtures thereof; and
the additive is chosen from gluconolactone, glucoheptonolactone, glucooctanoic lactone, gulonic acid lactone, mannonic acid lactone, ribonic acid lactone, and combinations thereof.
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Abstract
Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
463 Citations
20 Claims
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1. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising a coating layer overlying an exterior surface of the medical device, the coating layer comprising a therapeutic agent and an additive, wherein:
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the therapeutic agent is chosen from paclitaxel, rapamycin, and mixtures thereof; and the additive is chosen from gluconolactone, glucoheptonolactone, glucooctanoic lactone, gulonic acid lactone, mannonic acid lactone, ribonic acid lactone, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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7. A balloon catheter for delivering a therapeutic agent to a blood vessel, the catheter comprising:
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an elongate member having a lumen and a distal end; an expandable balloon attached to the distal end of the elongate member and in fluid communication with the lumen; and a coating layer overlying an exterior surface of the balloon, the coating layer comprising a therapeutic agent and an additive, wherein; the therapeutic agent is chosen from paclitaxel, rapamycin, and mixtures thereof; and the additive is chosen from gluconolactone, glucoheptonolactone, glucooctanoic lactone, gulonic acid lactone, mannonic acid lactone, ribonic acid lactone, and combinations thereof. - View Dependent Claims (8, 9, 10, 11)
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Specification