Hair follicle graft from tissue engineered skin
First Claim
Patent Images
1. A method of making a hair graft, comprising:
- a) incubating a tissue engineered dermal layer on a bioabsorbable scaffold until the tissue engineered dermal layer attaches to the bioabsorable scaffold;
b) placing hair follicle progenitor cells on the tissue engineered dermal layer;
c) placing a tissue engineered epidermal layer comprising a sheet of keratinocytes on the hair follicle progenitor cells to form a construct;
d) allowing the construct to mature in vitro; and
e) cutting the construct into one or more implantable grafts.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.
-
Citations
17 Claims
-
1. A method of making a hair graft, comprising:
- a) incubating a tissue engineered dermal layer on a bioabsorbable scaffold until the tissue engineered dermal layer attaches to the bioabsorable scaffold;
b) placing hair follicle progenitor cells on the tissue engineered dermal layer;
c) placing a tissue engineered epidermal layer comprising a sheet of keratinocytes on the hair follicle progenitor cells to form a construct;
d) allowing the construct to mature in vitro; and
e) cutting the construct into one or more implantable grafts. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- a) incubating a tissue engineered dermal layer on a bioabsorbable scaffold until the tissue engineered dermal layer attaches to the bioabsorable scaffold;
Specification