×

Isolated in vitro cell population comprising primate pluripotent stem cells containing a nucleic acid construct and differentiated progeny of the pluripotent stem cells

  • US 9,023,645 B2
  • Filed: 03/15/2013
  • Issued: 05/05/2015
  • Est. Priority Date: 11/27/2000
  • Status: Expired due to Fees
First Claim
Patent Images

1. An isolated in vitro cell population comprising differentiated cells and less than 1% primate pluripotent stem (pPS) cells, wherein the differentiated cells are the progeny of the pPS cells, and wherein the differentiated cells and the pPS cells comprise a nucleic acid molecule comprising the structure P-X,wherein X is a nucleic acid sequence encoding a product that is lethal to a cell in which it is expressed or renders a cell in which it is expressed susceptible to a lethal effect of an external agent, andwherein P is a transcriptional control element that is expressed in the pPS cells and down regulated when the pPS cells are induced to differentiate.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×