Methods and compositions for preventing or treating ophthalmic conditions
First Claim
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1. A method for treating an ophthalmic condition in a subject in need thereof, comprising administering to the subject a peptide represented by the formula D-Arg-2′
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-Dmt-Lys-Phe-NH2 or Phe-D-Arg- Phe-Lys-NH2, wherein the ophthalmic condition is selected from the group consisting of;
iris rubeosis, neovascular glaucoma, cotton wool patches, retinal edema, hard exudates, capillary microaneurysms, and dot hemorrhages, and wherein the subject is diagnosed as having or suspected of having said ophthalmic condition.
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Abstract
The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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Citations
9 Claims
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1. A method for treating an ophthalmic condition in a subject in need thereof, comprising administering to the subject a peptide represented by the formula D-Arg-2′
- 6′
-Dmt-Lys-Phe-NH2 or Phe-D-Arg- Phe-Lys-NH2, wherein the ophthalmic condition is selected from the group consisting of;
iris rubeosis, neovascular glaucoma, cotton wool patches, retinal edema, hard exudates, capillary microaneurysms, and dot hemorrhages, and wherein the subject is diagnosed as having or suspected of having said ophthalmic condition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification