Phase-separated block copolymer coatings for implantable medical devices

• US 9,028,859 B2
• Filed: 07/07/2006
• Issued: 05/12/2015
• Est. Priority Date: 07/07/2006
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Hossainy, Syed F. A., Glauser, Thierry
• Primary Examiner(s): Long, Scott
• Assistant Examiner(s): Alawadi, Sarah
• Application Number:
  US11/482,599
• Publication Number:
  US 20080008739A1
• Time in Patent Office: 3,231 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 53/00 Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Abstract

Medical devices and coatings for medical devices are disclosed, including methods for forming the devices and coatings. The devices and coatings comprise a phase-separated block copolymer matrix and one or more active agents. The phase-separated block copolymer matrix can be used to modulate the release-rate of one or more active agents from the medical device.

Claims

1. A medical device comprising a phase-separated block copolymer of two or more polymer blocks and the medical device comprising two or more active agents;

wherein the phase-separated block copolymer comprises two or more phase domains;

wherein a first active agent is preferentially incorporated in a first phase domain and a second active agent is preferentially incorporated in a second phase domain, and wherein the first and the second active agents have different release-rate profiles from the two or more phase domains in the phase-separated block copolymer;

wherein the two or more phase domains of the phase-separated block copolymer comprise a hydrophobic phase domain which comprises a hydrophobic block and a hydrophilic phase domain which comprises a hydrophilic block;

wherein

the first phase domain comprises the hydrophobic phase domain and the second phase domain comprises the hydrophilic phase domain;

or

the first phase domain comprises the hydrophilic phase domain and the second phase domain comprises the hydrophobic phase domain;

wherein the hydrophilic block of the block copolymer comprises a hydrophilic constituent monomer selected from the group consisting of PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethyl-phosphorylcholine (MPC), n-vinyl pyrrolidone (VP), alkoxymethacrylates, alkoxyacrylates, 2-methacryloylethyl phosphoryl choline, phosphoryl choline methacrylate, 2-acrylamido-2-methyl-1-propanesulfonic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate (SPMA), vinylsulfonic acid, 4-styrenesulfonic acid, 2-allyoxy-2-hydroxypropanesulfonic acid, and combinations thereof;

and

wherein the hydrophobic block of the block copolymer comprises a hydrophobic constituent monomer selected from the group consisting of 3-hydroxyhexanoate, 4-hydroxyhexanoate, and combinations thereof.

2. The medical device of claim 1, wherein the medical device is a stent.

3. The medical device of claim 1, wherein the medical device is fully absorbable.

4. The medical device of claim 1, wherein the medical device comprises a substrate and a coating, the coating comprising the phase-separated block copolymer and at least the first and the second active agents, wherein the coating is disposed on at least a portion of the substrate.

5. The medical device of claim 4, wherein the medical device further comprises a primer layer and the coating is disposed on at least a portion of the primer layer.

6. The medical device of claim 1, wherein the hydrophilic phase domain comprises hydrophilic polymer block(s), the hydrophilic polymer block(s) being block(s) of the block copolymer, and the block copolymer comprising between 5% and 30% by weight hydrophilic block(s).

7. The medical device of claim 1, wherein at least one active agent of the two or more active agents is a hydrophobic active agent and the release rate of the hydrophobic active agent from the medical device is increased by the hydrophilic phase domain.

8. The medical device of claim 1, wherein the release-rate of at least one of the two or more active agents of the medical device from the hydrophilic phase domain is greater than the release-rate of at least another of the two or more active agents of the medical device from the hydrophobic phase domain.

9. The medical device of claim 1, wherein the phase-separated block copolymer comprises a hard phase domain;

and wherein the first phase domain comprises the hard phase domain, or wherein the second phase domain comprises the hard phase domain, or wherein the block copolymer comprises more than two phase domains and neither the first nor the second phase domain comprises the hard phase domain.

10. The medical device of claim 9, wherein the hard phase domain is crystalline.

11. The medical device of claim 9, wherein the hard phase domain comprises stacking of polymer moieties.

12. The medical device of claim 11, wherein the moieties of the hard phase domain are aromatic rings.

13. The medical device of claim 1, wherein the phase-separated block copolymer comprises a soft phase domain;

and wherein the first phase domain comprises the soft phase domain, or wherein the second phase domain comprises the soft phase domain, or wherein the block copolymer comprises more than two phase domains and neither the first nor the second phase domain comprises the soft phase domain.

14. The medical device of claim 13, wherein at least one of the two or more active agents of the medical device is preferentially incorporated in the soft phase domain, and if the block copolymer comprises more than two phase domains and neither the first nor the second phase domain comprises the soft phase domain, then the medical device comprises three or more active agents.

15. The medical device of claim 1, wherein one of the phase domains is hydrogen bonded;

and wherein the hydrophilic phase domain is hydrogen bonded, or wherein the block copolymer comprises more than two phase domains, and neither the first nor the second phase domain is hydrogen bonded.

16. The medical device of claim 15, wherein the hydrogen bonded phase domain comprises at least one of the two or more active agents of the medical device, wherein the active agent forms hydrogen bonds with moieties of the phase domain;

and wherein if the block copolymer comprises more than two phase domains and neither the first nor the second phase domain comprises the hydrogen bonded phase domain, then the medical device comprises three or more active agents.

17. The medical device of claim 1, wherein one of the phase domains is crystalline.

18. The medical device of claim 1, wherein all or substantially all of the first active agent in the first phase domain is released in less than 15 days, and wherein all or substantially all of the second active agent in the second phase domain is released in a period of time greater than 15 days.

19. The medical device of claim 1, wherein the hydrophilic constituent monomer of the hydrophilic block of the block copolymer is selected from the group consisting of PEG acrylate (PEGA), PEG methacrylate, 2-methacryloyloxyethyl-phosphorylcholine (MPC), n-vinyl pyrrolidone (VP), and combinations thereof.

20. The medical device of claim 1, wherein the hydrophilic constituent monomer of the hydrophilic block of the block copolymer is selected from the group consisting of 2-acrylamido-2-methyl-1-propanesulfonic acid, 3-sulfopropyl acrylate, 3-sulfopropyl methacrylate (SPMA), vinylsulfonic acid, 4-styrenesulfonic acid, 2-allyoxy-2-hydroxypropanesulfonic acid, and combinations thereof.

21. The medical device of claim 1, wherein the hydrophilic block of the block copolymer comprises a second hydrophilic monomer selected from the group consisting of dextrin, elastin, 2-methacryloylethyl phosphoryl choline, phosphoryl choline, methacrylate, and combinations thereof.