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RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)

  • US 9,029,341 B2
  • Filed: 08/12/2011
  • Issued: 05/12/2015
  • Est. Priority Date: 08/17/2010
  • Status: Active Grant
First Claim
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1. A double-stranded short interfering nucleic acid (siNA) molecule that inhibits expression of the Hepatitis B virus (HBV), comprising a sense strand comprising the nucleotide sequence 5′

  • -uuCCgcagUauGGaUCGGCUsU-3′

    (SEQ ID NO;

    376) and an antisense strand comprising the nucleotide sequence 5′

    -B GccGAuccAuAcuGcGGAAUsU B-3′

    (SEQ ID NO;

    224),wherein B is an inverted a basic moiety;

    the bolded nucleotides comprise 2′

    -O-methyl modifications, the lower case nucleotides comprise 2′

    -fluoro modifications, and the s is a phosphorothioate linkage.

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