Porous particles and methods of making them
First Claim
1. A porous particle comprising a water-insoluble polymer that provides a continuous polymeric solid phase including an external particle surface, and one or more discrete cavities having inner walls and that are dispersed within the continuous polymeric solid phase,wherein the porous particle further comprises a cavity stabilizing hydrocolloid on the inner walls of the one or more discrete cavities, and an amphiphilic block copolymer that is disposed at the interface of the one or more discrete cavities and the continuous polymeric solid phase.
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Abstract
Porous particles can be prepared using an evaporative limited coalescence process in which one or more discrete cavities are stabilized within the continuous polymeric solid phase of the porous particles. The one or more discrete cavities have inner walls and are dispersed within the continuous polymeric solid phase. The porous particles further comprise a cavity stabilizing hydrocolloid on the inner walls of the one or more discrete cavities, and an amphiphilic (low HLB) block copolymer that is disposed at the interface of the discrete cavities and the continuous polymeric solid phase.
20 Citations
23 Claims
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1. A porous particle comprising a water-insoluble polymer that provides a continuous polymeric solid phase including an external particle surface, and one or more discrete cavities having inner walls and that are dispersed within the continuous polymeric solid phase,
wherein the porous particle further comprises a cavity stabilizing hydrocolloid on the inner walls of the one or more discrete cavities, and an amphiphilic block copolymer that is disposed at the interface of the one or more discrete cavities and the continuous polymeric solid phase.
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11. A method for preparing a porous particle, comprising:
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providing;
(a) a first aqueous phase comprising a cavity stabilizing hydrocolloid, and (b) an oil phase comprising a water-insoluble polymer or polymer precursor, an amphiphilic block copolymer and optionally an organic solvent,dispersing the first aqueous phase in the oil phase to form a water-in-oil emulsion, dispersing the water-in-oil emulsion in a second aqueous phase containing a surface stabilizing material to form a water-in-oil-in-water emulsion containing droplets of the water-in-oil emulsion, removing the organic solvent of the oil phase from the water-in-oil-in-water emulsion, or polymerizing a polymer precursor if present, to form a solidified precursor porous particle comprising a water-insoluble polymer that provides a continuous polymeric solid phase including an external particle surface, and one or more discrete cavities having inner walls and that are dispersed within the continuous polymeric solid phase, wherein the solidified precursor porous particle further comprises the cavity stabilizing hydrocolloid on the inner walls of the one or more discrete cavities, and the amphiphilic (low HLB) block copolymer that is disposed at the interface of the one or more discrete cavities and the continuous polymeric solid phase, and isolating the solidified precursor porous particle to provide a porous particle. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification