Internal resonance matching between an implanted device and an external device

• US 9,031,653 B2
• Filed: 07/26/2013
• Issued: 05/12/2015
• Est. Priority Date: 07/26/2012
• Status: Active Grant

• Current Assignee: Nyxoah SA
• Original Assignee: Nyxoah SA
• Inventors: Mashiach, Adi
• Primary Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US13/951,590
• Publication Number:
  US 20140031889A1
• Time in Patent Office: 655 Days
• Field of Search: 607 60- 61, 607/42, 607/134
• US Class Current: 607/42
• CPC Class Codes: A61B 17/0482 Needle or suture guides guides for drills, pins or wire A61B17/17; for puncturing needles A61B17/3403
• CPC Class Codes: A61N 1/0526 Head electrodes A61N1/0551 takes precedence
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3606 adapted for a particular treatment
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36189 using modulation techniques
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/3787 from an external energy source
• CPC Class Codes: H02J 50/05 using capacitive coupling
• CPC Class Codes: H02J 50/12 of the resonant type
• CPC Class Codes: H04B 5/26 using coils
• CPC Class Codes: H04B 5/266 One coil at each side, e.g. with primary and secondary coils
• CPC Class Codes: H04B 5/72 for local intradevice communication
• CPC Class Codes: H04B 5/79 for data transfer in combination with power transfer
• CPC Class Codes: Y10T 29/49018 with other electrical component

Abstract

A unit configured for implantation in a subject'"'"'s body may include a carrier, an implantable circuit associated with the carrier, an antenna arranged on the carrier and configured to wirelessly receive energy from a location external to the subject'"'"'s body and to provide at least a portion of the energy to the implantable circuit, and at least one component associated with the carrier for receiving energy from the implantable circuit. Wherein the implantable circuit and the antenna have an internal resonant frequency mismatched from an external resonant frequency of an external circuit, to account for resonance frequency variation as a result of implantation in the subject'"'"'s body.

Claims

1. An implantable device for treating sleep apnea in a subject, the device, comprising:

a flexible carrier adapted to be implanted in a region of a genioglossus muscle;

an implantable circuit associated with the flexible carrier, the implantable circuit being adapted to stimulate a hypoglossal nerve and modulate a genioglossus muscle;

an antenna arranged on the flexible carrier and configured to wirelessly receive energy from a location external to a body of the subject and to provide at least a portion of the energy to the implantable circuit;

at least one component associated with the flexible carrier for receiving energy from the implantable circuit; and

a layer encapsulating at least a portion of the flexible carrier, implantable circuit, and the antenna;

wherein the implantable circuit and the antenna have a first internal resonant frequency and are adapted for a resonance frequency variation based on implantation by being configured to have a second internal resonant frequency different from the first internal resonant frequency and matched to an external resonant frequency of an external circuit for communicating with the antenna of the implantable device, when the layer absorbs a fluid and causes a change from the first internal resonant frequency to the second internal resonant frequency.

2. The implantable device of claim 1, wherein the flexible carrier includes biocompatible material.

3. The implantable device of claim 1, further including at least one pair of modulation electrodes arranged on the flexible carrier.

4. The implantable device of claim 1, further comprising a capacitance associated with the implantable circuit, wherein an amount of mismatch between the first internal resonant frequency and the external resonant frequency depends on the capacitance.

5. The implantable device of claim 4, wherein the implantable circuit includes at least one trimming capacitor to enable changing of the capacitance associated with the implantable circuit.

6. The implantable device of claim 4, wherein the implantable circuit includes a plurality of capacitors that may be selectively connected to the implantable circuit in order to provide the capacitance associated with the implantable circuit.

7. The implantable device of claim 6, wherein the capacitance associated with the implantable circuit is provided by a subset of the plurality of capacitors.

8. The implantable device of claim 6, wherein at least one of the plurality of capacitors does not contribute to the capacitance associated with the implantable circuit.

9. The implantable device of claim 4, wherein the capacitance associated with the implantable circuit is set prior to implantation of the implantable device in the subject'"'"'s body.

10. The implantable device of claim 4, wherein the capacitance to be associated with the implantable circuit is determined through simulation based on an expected value of the resonance frequency variation.

11. The implantable device of claim 4, wherein the capacitance to be associated with the implantable circuit is determined based on at least one of the following parameters:

a placement location of the implantable device in the subject'"'"'s body, an amount of energy required to modulate a nerve, a type of electronics present on the implantable circuit, and an estimation of moisture incursion into a capsule encapsulating the implantable device.

12. The implantable device of claim 4, wherein the capacitance associated with the implantable circuit is set prior to encapsulation of the implantable device.

13. The implantable device of claim 4, wherein the capacitance associated with the implantable circuit is adapted to cause the difference between the first internal resonant frequency of the implantable circuit of the implantable device implanted in the subject'"'"'s body and the external resonant frequency of the external circuit to be no more than 30% of the external resonant frequency.

14. The implantable device of claim 4, wherein the capacitance associated with the implantable circuit is adapted to cause energy transfer between the external circuit and the implantable circuit to have an energy transfer efficiency of at least 50%.

15. The implantable device of claim 1, wherein the resonance frequency variation of the implantable circuit as a result of implantation includes a change from the first internal resonant frequency of about 8.1 kHz to the second internal resonant frequency of about 7.9 kHz.

16. A sleep-apnea therapy unit configured for implantation in a subject'"'"'s body, comprising:

a flexible carrier;

an implantable circuit associated with the flexible carrier;

an antenna arranged on the flexible carrier and configured to wirelessly receive energy from a location external to the subject'"'"'s body and to provide at least a portion of the energy to the implantable circuit;

at least one component associated with the flexible carrier for receiving energy from the implantable circuit; and

a layer encapsulating at least a portion of the flexible carrier, implantable circuit, and the antenna;

wherein the implantable circuit and the antenna have a first internal resonant frequency and are configured to have a second internal resonant frequency different than the first internal resonant frequency and matched to an external resonant frequency of an external circuit for communicating with the antenna implantable device, when the layer absorbs a fluid and causes a change from the first internal resonant frequency to the second internal resonant frequency after the therapy unit is implanted.

17. An implantable device for treating sleep apnea in a subject, the device, comprising:

a flexible carrier adapted to be implanted in a region of a genioglossus muscle;

an implantable circuit associated with the flexible carrier, the implantable circuit being adapted to stimulate a hypoglossal nerve and modulate a genioglossus muscle;

an antenna arranged on the flexible carrier and configured to wirelessly receive energy from a location external to a body of the subject and to provide at least a portion of the energy to the implantable circuit; and

at least one component associated with the flexible carrier for receiving energy from the implantable circuit;

wherein the implantable circuit and the antenna have a first internal resonant frequency and are adapted for a resonance frequency variation based on implantation by being configured to have a second internal resonant frequency different from the first internal resonant frequency and matched to an external resonant frequency of an external circuit for communicating with the antenna of the implantable device, when the flexible carrier absorbs moisture and causes a change from the first internal resonant frequency to the second internal resonant frequency.