Wireless neural recording and stimulating system

• US 9,031,658 B2
• Filed: 10/14/2008
• Issued: 05/12/2015
• Est. Priority Date: 10/14/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Chiao, Jung-Chih, Ativanichayaphong, Thermpon, Peng, Yuan B., He, Ji Wei
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US12/251,368
• Publication Number:
  US 20090157141A1
• Time in Patent Office: 2,401 Days
• Field of Search: 607 40- 46
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Apparatus and methods are provided for the management of neural activity in an individual. Nerve activity is sensed and correlated with sensations such as pain. In response and without requiring input from the individual, although external input is contemplated, a signal is transmitted to another component for electrical stimulation that alters neural activity. Also, the modulation of the signals between the sensor and stimulator may be modified by a third component independently, independent of, or including user inputs.

Claims

1. A neurostimulation system for mitigating pain comprising:

at least one implantable sensor that is configured to measure a neuronal signal from a first neuron and to wirelessly transmit the neuronal signal;

at least one implantable stimulator configured to wirelessly receive a stimulation command signal, wherein the implantable stimulator is configured to generate an electrical signal in response to the stimulation command signal, wherein the generated electrical signal is configured to be applied directly to a second neuron to alter neural activity at the first neuron, wherein the first neuron and the second neuron are on a neural pathway, wherein the neural pathway includes at least one of a spinal-thalamus-somatosensory pathway and a cortico-ponto-spinal decending pathway; and

a remote processing device configured to;

receive the wirelessly transmitted neuronal signal from the implantable sensor;

receive a selection of a pain threshold based on input from a patient;

determine a pain level based on the wirelessly transmitted neuronal signal;

determine a stimulation command signal based on the determined pain level and the selected pain threshold; and

wirelessly transmit the stimulation command signal to the implantable stimulator.

2. The system of claim 1, the implantable sensor comprising a deformable substrate and at least one electrode.

3. The system of claim 1, further comprising a plurality of sensors and stimulators arranged in a wireless body area network, wherein the remote processing device is configured to selectively transmit a stimulation command signal to a particular one of the plurality of stimulators, wherein the particular one of the stimulators includes a radio frequency identification (RFID) mechanism.

4. The system of claim 1, wherein the remote processing device includes software for predicting pain levels and adapting the system to the dynamic conditions of a neurological system.

5. The system of claim 1, wherein determine a pain level comprises predicting a pain level using a regression tree model, wherein the regression tree model is constructed using factors including graded mechanical stimuli and classification of neurons.

6. The system of claim 1, wherein determine a pain level comprises determining a rate of spikes of action potentials.

7. The system of claim 1, wherein determine a stimulation command comprises determining that which increases the intensity of an electrical signal generated by the stimulator relative to the intensity of an electrical signal generated by the stimulator as a result of a previously determined stimulation command if a previously determined pain level was above the pain threshold and a current determined pain level is above the pain threshold.

8. The system of claim 1, wherein the remote processing device is configured to generate a radio-frequency signal, and wherein the sensor is configured to harvest radio-frequency energy from the radio-frequency signal.

9. The system of claim 8, wherein the sensor includes a charge pump, a rectifier, and a pulse generator.

10. The system of claim 8, the radio-frequency signal comprising an identifier and the sensor comprising an identification, wherein the sensor is configured to harvest the radio-frequency energy from the radio-frequency signal if the identifier is the same as the identification.

11. The system of claim 8, wherein the stimulator is configured to harvest the radio-frequency energy from the radio-frequency signal.

12. The system of claim 11, wherein the stimulator includes a charge pump.

13. The system of claim 1, wherein the neural pathway provides a direct electrical connection between the first neuron and the second neuron.

14. The system of claim 1, further comprising a plurality of sensors and stimulators arranged in a wireless body area network, wherein the remote processing device is configured to determine the effect of an electrical signal generated by different combinations of one or more of the stimulators on the neuronal signal measured by different combinations of one or more of the sensors.

15. A method of electrical neurostimulation to mitigate pain comprising the steps:

recording a neuronal signal from a first neuron with an implanted sensor, wherein first neuron is on a neural pathway, wherein the neural pathway includes at least one of a spinal-thalamus-somatosensory pathway and a cortico-ponto-spinal decending pathway; and

wirelessly transmitting the recorded neuronal signal to a remote processing device, by the remote processing device;

receiving a selection of a pain threshold based on input from a patient;

determining a pain level based on the wirelessly transmitted neuronal signal;

determining a stimulation command signal based on the determined pain level and the selected pain threshold; and

wirelessly transmitting the stimulation command signal to an implantable stimulator, wherein the implantable stimulator is configured to apply an electrical signal directly to a second neuron, wherein the second neuron is on the neural pathway; and

by the stimulator, generating an electrical signal in response to the stimulation command signal, wherein the electrical signal is configured to alter neural activity at the first neuron.

16. The method of claim 15, wherein the sensor is implanted in the spinal cord.

17. The method of claim 15, wherein determining a pain level includes using a regression tree model.

18. The method of claim 15, wherein the stimulation command signal is determined and transmitted when the pain level is greater than the selected pain threshold, wherein the determined pain level is based on an action potential rate.

19. The method of claim 15 wherein the stimulator is implanted in a stimulating site selected from the primary somatosensory cortex (SI), secondary somatosensory cortex (SII), anterior cingulate cortex (ACC), prefrontal cortex, insular cortex, thalamus, septum, and the sensory area of the thalamus, spinal cord, motor cortex, brain stem, periaqueductal gray (PAG), periventricular gray, precentral gyrus, cingulate, caudate, amygdala, parietal cortex, zona incerta, mesencephalic, pontin and medullary retricular formations, superior colliculus, inferior colliculus, nucleus cuneiformis, locus coeruleus, parabrachial nucleus, nucleus ambiguus, nucleus raphe magnus, nucleus reticularis paragigantocellularis, nucleus reticularis gigantocellularis pars alpha (NRGa), raphe pallidus, nucleus tractus solitaris, and spinal trigeminal nucleus spinal cord.

20. The method of claim 15, further comprising a plurality of sensors and a plurality of stimulators implanted throughout the body to form a body area network.