Cannula for minimizing dilution of dosing during nitric oxide delivery
First Claim
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1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising:
- a nitric oxide lumen and an oxygen lumen;
the nitric oxide lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide to a patient, andthe oxygen lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient; and
the nitric oxide lumen and the oxygen lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the nitric oxide lumen and (ii) the oxygen lumen such that the flow path for the first therapeutic gas delivers the first therapeutic gas to both a first nostril and a second nostril of a patient and the flow path for the second therapeutic gas delivers the second therapeutic gas to both the first and second nostrils of the patient without mixing the first therapeutic gas and the second therapeutic gas in the cannula nosepiece when connected to a first gas source comprising nitric oxide and a second gas source comprising oxygen; and
the flow path for the first therapeutic gas at the cannula nosepiece having an inner diameter that is smaller than an inner diameter of the nitric oxide lumen.
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Abstract
The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.
600 Citations
33 Claims
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1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising:
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a nitric oxide lumen and an oxygen lumen; the nitric oxide lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide to a patient, and the oxygen lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient; and the nitric oxide lumen and the oxygen lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the nitric oxide lumen and (ii) the oxygen lumen such that the flow path for the first therapeutic gas delivers the first therapeutic gas to both a first nostril and a second nostril of a patient and the flow path for the second therapeutic gas delivers the second therapeutic gas to both the first and second nostrils of the patient without mixing the first therapeutic gas and the second therapeutic gas in the cannula nosepiece when connected to a first gas source comprising nitric oxide and a second gas source comprising oxygen; and the flow path for the first therapeutic gas at the cannula nosepiece having an inner diameter that is smaller than an inner diameter of the nitric oxide lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising:
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a nitric oxide lumen and an oxygen lumen; the nitric oxide lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide to a patient, and the oxygen lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient; the nitric oxide lumen and the oxygen lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the nitric oxide lumen and (ii) the oxygen lumen when connected to a first gas source comprising nitric oxide and a second gas source comprising oxygen; the nitric oxide lumen having an inner diameter that is smaller than an inner diameter of the oxygen lumen; and wherein the flow path for the first therapeutic gas at the cannula nosepiece comprises a first prong, a second prong and a backplane, with the first prong being in fluid communication with the second prong via the backplane, and the inner diameter of the nitric oxide lumen being larger than an inner diameter of the flow path for the first therapeutic gas at the cannula nosepiece. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A nasal cannula for therapeutic gas delivered to a patient in need thereof, the nasal cannula comprising:
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a first lumen and a second lumen; the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide gas to a patient when connected to a first gas source comprising nitric oxide, and the second lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient when connected to a a second gas source comprising oxygen; the first lumen and the second lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the first therapeutic gas lumen and (ii) the second therapeutic gas lumen; wherein the flow path for the first therapeutic gas at the cannula nosepiece comprises a first prong, a second prong and a backplane, with the first prong being in fluid communication with the second prong via the backplane, and the flow path for the first therapeutic gas at the cannula nosepiece has a volume that is less than 0.035 mL; the first therapeutic gas lumen having an inner diameter that is smaller than an inner diameter of the second therapeutic gas lumen; and the inner diameter of the first therapeutic gas being larger than an inner diameter of the flow path for the first therapeutic gas at the cannula nosepiece. - View Dependent Claims (26)
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27. A method for treating pulmonary hypertension, the method comprising:
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administering a pulse of nitric oxide gas to a patient through a nasal cannula, wherein the nasal cannula comprises; a first lumen and a second lumen; the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide gas to a patient when connected to a first gas source comprising nitric oxide, and the second lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient when connected to a second gas source comprising oxygen, and the first lumen and the second lumen aggregating at a cannula nosepiece, the cannula nosepiece having separate flow paths to the patient for (i) the first therapeutic gas lumen and (ii) the second therapeutic gas lumen; the flow path for the first therapeutic gas at the cannula nosepiece comprising a first prong, a second prong and a backplane, with the first prong being in fluid communication with the second prong via the backplane; the first therapeutic gas lumen having an inner diameter that is smaller than an inner diameter of the second therapeutic gas lumen; and the inner diameter of the first therapeutic gas lumen being larger than an inner diameter of the flow path for the first therapeutic gas at the cannula nosepiece. - View Dependent Claims (28, 29, 30, 31, 32, 33)
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Specification