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Method for control of post-prandial glucose

  • US 9,034,323 B2
  • Filed: 09/24/2013
  • Issued: 05/19/2015
  • Est. Priority Date: 04/28/2008
  • Status: Expired due to Fees
First Claim
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1. A method for controlling post-prandial glucose levels in a subject, comprising administering to the subject a regular insulin and a hyaluronan-degrading enzyme between 5 and 15 minutes before a meal, whereby the action of the regular insulin has an onset and a duration of action of a fast-acting insulin analog, wherein:

  • the amount of hyaluronan degrading enzyme administered is sufficient so that the regular insulin can be administered between 5 and 15 minutes before a meal;

    the sufficient amount of a hyaluronan degrading enzyme is 1 Unit or more hyaluronidase activity/mL; and

    administration of the regular insulin and the hyaluronan degrading enzyme is effected via subcutaneous, intradermal, intramuscular or intraperitoneal administration.

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