Porous osteoimplant
First Claim
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1. A method of making a porous composite comprising steps of:
- providing a plurality of particles comprising a bone-derived material, an inorganic material, a bone substitute material, or any combination thereof;
providing a biocompatible polymer and a plasticizer comprising poly(ethylene glycol) (PEG);
mixing the plurality of particles, the biocompatible polymer, and the plasticizer to obtain a mixture; and
submitting the mixture to a supercritical fluid treatment that comprises steps of;
contacting the mixture with a supercritical fluid having a maximum pressure of about 7500 to about 8000 psi, andreturning the supercritical fluid to a non-supercritical state by rapid or explosive decompression to atmospheric pressure in about 60 seconds to about 90 seconds, so that the porous composite is obtained, the porous composite having a wet compressive strength between about 3 MPa to about 5 MPa and having the PEG in an amount comprising 1-40% by weight of the porous composite.
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Abstract
The invention is directed toward porous composites for application to a bone defect site to promote new bone growth. The inventive porous composites comprise a biocompatible polymer and a plurality of particles of bone-derived material, inorganic material, bone substitute material or composite material. In certain embodiments, the porous composites are prepared using a method that includes a supercritical fluid (e.g., supercritical carbon dioxide) treatment. The invention also discloses methods of using these composites as bone void fillers.
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Citations
29 Claims
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1. A method of making a porous composite comprising steps of:
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providing a plurality of particles comprising a bone-derived material, an inorganic material, a bone substitute material, or any combination thereof; providing a biocompatible polymer and a plasticizer comprising poly(ethylene glycol) (PEG);
mixing the plurality of particles, the biocompatible polymer, and the plasticizer to obtain a mixture; andsubmitting the mixture to a supercritical fluid treatment that comprises steps of; contacting the mixture with a supercritical fluid having a maximum pressure of about 7500 to about 8000 psi, and returning the supercritical fluid to a non-supercritical state by rapid or explosive decompression to atmospheric pressure in about 60 seconds to about 90 seconds, so that the porous composite is obtained, the porous composite having a wet compressive strength between about 3 MPa to about 5 MPa and having the PEG in an amount comprising 1-40% by weight of the porous composite. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification