Composition comprising biodegradable hydrating ceramics for controlled drug delivery
First Claim
1. A pharmaceutical composition which, when solidified, has a ruptured structure, said composition consisting ofi) one or more biodegradable hydrating ceramics;
- ii) one or more agents in an amount sufficient to contribute to the creation of the ruptured structure, wherein said one or more agents area) one or more gas-forming agents creating a foam-like structure, wherein the foam-like structure has openings, wherein at least 50% or more of the openings have a maximum width of at least about 0.1 mm;
orb) one or more disintegrants capable of disintegrating the solidified material into two or more parts;
iii) one or more therapeutically and/or diagnostically active substances; and
iv) sorbed aqueous medium.
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Abstract
The present invention relates to a drug carrier composition comprising i) one or more biodegradable hydrating ceramics ii) one or more expandable agents, and iii) sorbed aqueous medium which in solid form has a ruptured structure. The function of the expandable agent is to create a ruptured structure in the solidified composition, either a foam-like structure or a disintegrated structure where it is split into a large number of parts, particles, units, granules or pieces, so as to obtain an enlarged apparent surface area that is exposed to degradation or erosion upon administration. Suitable substances to obtain this surface enlarging effect are gas-forming agents or swelling agents, gelling agents or disintegrants, here referred to as expandable agents. The expandable agents may be bioresorbable or non-bioresorbable.
27 Citations
19 Claims
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1. A pharmaceutical composition which, when solidified, has a ruptured structure, said composition consisting of
i) one or more biodegradable hydrating ceramics; -
ii) one or more agents in an amount sufficient to contribute to the creation of the ruptured structure, wherein said one or more agents are a) one or more gas-forming agents creating a foam-like structure, wherein the foam-like structure has openings, wherein at least 50% or more of the openings have a maximum width of at least about 0.1 mm;
orb) one or more disintegrants capable of disintegrating the solidified material into two or more parts; iii) one or more therapeutically and/or diagnostically active substances; and iv) sorbed aqueous medium. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification