Articles for tissue regeneration with biodegradable polymer

• US 9,034,367 B2
• Filed: 05/10/2007
• Issued: 05/19/2015
• Est. Priority Date: 05/10/2007
• Status: Active Grant

• Current Assignee: Cormatrix Cardiovascular, Inc.
• Original Assignee: Cormatrix Cardiovascular, Inc.
• Inventors: Matheny, Robert G., Lewis, Beecher C.
• Primary Examiner(s): FOX, ALLISON M
• Application Number:
  US11/747,028
• Publication Number:
  US 20080279824A1
• Time in Patent Office: 2,931 Days
• Field of Search: None
• US Class Current: 424/443
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: A61L 27/3604 characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
• CPC Class Codes: A61L 27/3629 Intestinal tissue, e.g. small intestinal submucosa
• CPC Class Codes: A61L 27/3633 Extracellular matrix [ECM]
• CPC Class Codes: A61L 27/3641 characterised by the site of application in the body materials for artificial blood vessels A61L27/507; materials for use in artificial skin A61L27/60
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The invention is to articles made from extracellular matrix sheets that encase biodegradable polymeric material. Methods of healing wounds or regenerating tissue at sites of defect by placing said articles in mammals are claimed. The biodegradable polymer can change quality upon contact with a physiological parameter such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The degradation of the polymer can be controlled to suit a tissue regeneration or wound healing time course. Additional components such as proteins, cells and drugs can be added to the biopolymer composition.

Claims

1. A tissue regeneration member, comprising:

an extracellular matrix (ECM) construct comprising a top member comprising a first sheet of first ECM comprising small intestine submucosa (SIS), said first sheet comprising first top and bottom surfaces, a bottom member comprising a second sheet of second ECM comprising liver basement membrane (LBM), said second sheet comprising second top and bottom surfaces, said first sheet first bottom surface and said second sheet second top surface being in communication with each other, wherein a construct space is formed therebetween, and a biodegradable composition disposed in said construct space, said biodegradable composition comprising an emulsion comprising poly ε

-caprolactone and third ECM selected from the group consisting of LBM and urinary bladder submucosa (UBS).

2. The tissue regeneration member of claim 1, wherein said ECM construct top member comprises a plurality of said first sheets of said first ECM.

3. The tissue regeneration member of claim 1, wherein said ECM construct bottom member comprises a plurality of said second sheets of said second ECM.

4. A method comprising:

a) identifying a defect or wound in mammalian tissue in a mammal,

b)providing the tissue regeneration member of claim 1,

c) contacting said defect or wound with said tissue regeneration member, and

d) regenerating tissue at said defect or healing said wound.

5. The method of claim 4, wherein said mammalian tissue is myocardial tissue.

6. The method of claim 4, wherein said mammalian tissue is pancreatic tissue.

7. The method of claim 4, wherein said mammalian tissue is liver tissue.