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Diabetes-related biomarkers and methods of use thereof

  • US 9,034,585 B2
  • Filed: 03/14/2013
  • Issued: 05/19/2015
  • Est. Priority Date: 10/11/2005
  • Status: Active Grant
First Claim
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1. A method of evaluating risk for developing a diabetic condition, the method comprising:

  • obtaining biomarker measurement data, wherein the biomarker measurement data is representative of measurements of biomarkers in at least one biological sample from an individual; and

    evaluating risk for developing a diabetic condition based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data;

    wherein said biomarkers comprise;

    (i) at least three biomarkers, where three of the biomarkers are selected from the RDMARKER sets listed in FIG. 6A;

    or(ii) at least four biomarkers selected from RDMARKERS;

    or(iii) at least three biomarkers, where two biomarkers are selected from ADIPOQ;

    CRP;

    GLUCOSE;

    GPT;

    HBA1C;

    HSPA1B;

    IGFBP1;

    IGFBP2;

    INS;

    LEP; and

    TRIG; and

    one biomarker is selected from the ALLDBRISKS, CPs, and TLRFs of Table 1, Table 2, and Table 3;

    or(iv) at least three biomarkers, where at least one biomarker is selected from GLUCOSE and HBA1C;

    at least one biomarker is selected from ADIPOQ, CRP, GPT, HSPA1B, IGFBP1, IGFBP2, INS, LEP, and TRIG; and

    at least one biomarker is selected from the ALLDBRISKS, CPs, and TLRFs of Table 1, Table 2, and Table 3;

    or(v) at least three biomarkers, where at least two biomarkers are selected from the biomarkers within the group consisting of Core Biomarkers I and Core Biomarkers II and at least a third biomarker is selected from any of the biomarkers listed in Table 4.

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