Sample metering device and assay device with integrated sample dilution
First Claim
1. A sensor cartridge for sensing at least one analyte in a sample, comprising:
- at least one sensor;
a sample chamber between a sample entry port and a sample isolation unit and including a diluent introduction port therebetween for introducing diluent into said sample chamber, wherein a region of the sample chamber between said dilution introduction port and said sample isolation unit defines a dilution chamber and a metered volume of sample for dilution;
a diluent package containing a diluent;
a diluent conduit configured for transporting diluent from the diluent package to the diluent introduction port;
a pump configured to transfer said diluent through the diluent conduit and the diluent introduction port, and into said dilution chamber to form a diluted sample, and further configured to transport the diluted sample to the at least one sensor; and
a pump conduit beginning at the pump and ending at an air introduction port on the diluent conduit.
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Accused Products
Abstract
In one embodiment, the invention is to a sample metering device, comprising a sample holding chamber oriented between a sample entry port and a sample isolation unit and having a diluent introduction port disposed therebetween for introduction of a diluent into the sample holding chamber. The volume within the sample holding chamber between the diluent introduction port and the sample isolation unit defines a metered volume of a sample for analysis. In another embodiment, the invention is to an apparatus and method for rapid determination of analytes in liquid samples by various assays including immunoassays incorporating a sample dilution feature, preferably suitable for low range sample dilution, and preferably capable of being used in the point-of-care diagnostic field.
59 Citations
22 Claims
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1. A sensor cartridge for sensing at least one analyte in a sample, comprising:
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at least one sensor; a sample chamber between a sample entry port and a sample isolation unit and including a diluent introduction port therebetween for introducing diluent into said sample chamber, wherein a region of the sample chamber between said dilution introduction port and said sample isolation unit defines a dilution chamber and a metered volume of sample for dilution; a diluent package containing a diluent; a diluent conduit configured for transporting diluent from the diluent package to the diluent introduction port; a pump configured to transfer said diluent through the diluent conduit and the diluent introduction port, and into said dilution chamber to form a diluted sample, and further configured to transport the diluted sample to the at least one sensor; and a pump conduit beginning at the pump and ending at an air introduction port on the diluent conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification