Medical devices

• US 9,035,037 B2
• Filed: 12/22/2008
• Issued: 05/19/2015
• Est. Priority Date: 12/21/2007
• Status: Active Grant

• Current Assignee: OcuNexus Therapeutics, Inc.
• Original Assignee: CoDa Therapeutics, Inc.
• Inventors: Becker, David L., Green, Colin R., Duft, Bradford James
• Primary Examiner(s): Bowman, Amy
• Application Number:
  US12/809,941
• Publication Number:
  US 20110166653A1
• Time in Patent Office: 2,339 Days
• Field of Search: None
• US Class Current: 536/24.5
• CPC Class Codes: A61K 38/08 Peptides having 5 to 11 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 38/10 Peptides having 12 to 20 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 38/385 Serum albumin
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 2300/25 Peptides having up to 20 amino acids in a defined sequence
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/258 Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
• CPC Class Codes: A61L 2300/432 Inhibitors, antagonists A61L2300/402 - A61L2300/43 take precedence
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Claims

1. A manufactured cardiovascular or orthopedic medical device for use or implantation in a mammal, comprising an anti-connexin 43 compound releasable upon insertion of the medical device to or within a subject.

2. The medical device of claim 1, wherein the anti-connexin 43 compound decreases connexin 43 protein expression.

3. The medical device of claim 1 wherein the anti-connexin 43 compound is an antisense oligonucleotide.

4. The medical device of claim 1 wherein the anti-connexin 43 compound is an siRNA or RNAi oligonucleotide.

5. The medical device of claim 1 wherein the anti-connexin 43 compound is a peptide compound.

6. The medical device of claim 5 wherein the peptide compound is a peptidomimetic.

7. The medical device of claim 1, wherein the anti-connexin 43 compound is an anti-connexin 43 antibody, F(v) fragment, Fab, fragment, Fab′

fragment or F(ab′

)₂ fragment.

8. The medical device of claim 1, wherein the anti-connexin 43 agent binds to connexin 43 mRNA.

9. The medical device of claim 8, wherein the antibody or antibody fragment is chimeric or humanized antibody.

10. The medical device of claim 1, wherein the anti-connexin agent binds to a connexin 43 hemichannel.

11. The medical device of claim 10, wherein the anti-connexin agent binds to a hemichannel extracellular loop.

12. The medical device of claim 1, wherein the anti-connexin agent is in a polynucleotide having a sequence selected for SEQ.ID.NOS.1 or 2 or a pharmaceutically acceptable salt thereof.

13. The medical device of claim 1, wherein the anti-connexin agent is a peptide having a sequence selected from SEQ.ID.NOS. 15 to 38 or a pharmaceutically acceptable salt thereof.

14. The medical device of claim 1, wherein the anti-connexin agent is a peptide of SEQ.ID.NOS. 18 or 19.

15. The medical device of claim 1, wherein the anti-connexin agent is a peptide of SEQ.ID.NO.19.

16. The medical device of claim 1, wherein the anti-connexin agent is a polynucleotide having a sequence selected from the group consisting of:

SEQ.ID.NOS.1 to 12.

17. The medical device of claim 1, wherein the surface of the medical device comprises an anti-connexin agent.

18. The medical device of claim 17, wherein the anti-connexin agent is present at a weight percentage of about 0.0001% to about 30%.

19. The medical device of claim 17, wherein the surface of the medical device contacts a target tissue within the subject upon use.

20. The medical device of claim 19, wherein the target tissue is heart tissue or vascular tissue.

21. The medical device of claim 1, wherein the release rate of the anti-connexin agent is controlled.

22. The medical device of claim 1, wherein the medical device provides for surface contact release of the anti-connexin agent.

23. The medical device of claim 1, wherein the medical device provides for the sustained release of the anti-connexin agent.

24. The medical device of claim 1, wherein the medical device provides for the slow release of the anti-connexin agent.

25. The medical device of claim 1, wherein the device comprises a coating containing an anti-connexin agent.

26. The medical device of claim 25, wherein the coating comprises a polymer.

27. The medical device of claim 25, wherein the coating comprises a plurality of layers of a polymer/anti-connexin agent mixture.

28. The medical device of claim 1, wherein the medical device is for implantation in a human.

29. The medical device of claim 1, wherein the medical device comprises a stent.

30. The medical device of claim 1, wherein the medical device comprises a suture.

31. The medical device of claim 1, wherein the medical device comprises a balloon, a prosthetic heart valve, an annuloplasty ring, a pulse generator, a cardiac defibrillator, an arteriovenous shunt, an anastomosis device, a hemostatic barrier or a pacemaker.

32. The medical device of claim 1, wherein the medical device comprises an orbital implant, a lens, a lens implant, or a corneal implant.

33. The medical device of claim 1, wherein the medical device comprises an orthopedic plate, a bone pin, a bone substitute, an anchor, a joint, a screw, or a vertebral disk.

34. The medical device of claim 1, wherein the medical device comprises a graft, a shunt, a vascular implant, a tissue scaffold, an intraluminal device or a vascular support.

35. The medical device of any of claim 29-33 or 34, wherein the medical device is for implantation in a human.

36. The medical device of claim 1, wherein the medical device comprises at least one channel formed in an outer surface thereof, and wherein the anti-connexin agent is included on and/or within at least one channel.

37. The medical device of claim 1, wherein at least a portion of the medical device is formed, in whole or in part, of a substance that includes the anti-connexin agent.

38. The medical device of claim 1, wherein the device further comprises one or more therapeutic agents.

39. The medical device of claim 1 wherein the subject is a mammal.

40. The medical device of claim 1 wherein the mammal is a human.

41. The medical device of claim 1 wherein the mammal is selected from the group consisting of domestic and pet animals, sports animals, farm animals, and zoo animals.

42. The medical device of claim 1 wherein the mammal is a horse, a dog, or a cat.