Systems and methods for performing quality review scoring of biomarkers and image analysis methods for biological tissue
First Claim
1. A computer-implemented method for performing quality review of analysis of biological tissue, the method comprising:
- rendering a graphical user interface on a visual display device;
rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue, the field of view selection component allowing the user to configure a color and/or a transparency of a representation on the graphical user interface of biological tissue corresponding to a selected field of view;
in response to user input selecting a field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue;
rendering, on the graphical user interface, a morphological analysis selection component allowing a user to select a morphological analysis of multiplexed biomarker image data corresponding to the selected field of view, the morphological analysis selection component allowing the user to configure a color and/or a transparency of a representation of a result of a selected morphological analysis;
in response to user input selecting a first morphological analysis at the morphological analysis selection component, overlaying, on the first image of the biological tissue, a representation of a first result of the selected first morphological analysis, the first result of the first morphological analysis indicating one or more morphological features of interest in the first image, wherein the first image of the biological tissue and the representation of the first result are displayed in a visually distinguishable manner; and
rendering, on the graphical user interface, a quality review selection component allowing the user to select a quality review score based on a comparison between the first image and the representation of the first result of the first morphological analysis rendered on the graphical user interface.
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Accused Products
Abstract
Exemplary embodiments include methods, systems, and devices for enabling users to provide quality scores for indicating the quality of image analysis methods performed on images of biological tissue. An exemplary user interface displays results of an image analysis method performed on an image of biological tissue in an overlaid manner on an image of biological tissue. The exemplary user interface enable a user to provide, directly on the user interface, one or more quality scores to indicate the user'"'"'s assessment of the quality of the image analysis performed on the image. Exemplary embodiments store the quality scores provided by the user in association with the image analysis method and the image of biological tissue.
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Citations
28 Claims
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1. A computer-implemented method for performing quality review of analysis of biological tissue, the method comprising:
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rendering a graphical user interface on a visual display device; rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue, the field of view selection component allowing the user to configure a color and/or a transparency of a representation on the graphical user interface of biological tissue corresponding to a selected field of view; in response to user input selecting a field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue; rendering, on the graphical user interface, a morphological analysis selection component allowing a user to select a morphological analysis of multiplexed biomarker image data corresponding to the selected field of view, the morphological analysis selection component allowing the user to configure a color and/or a transparency of a representation of a result of a selected morphological analysis; in response to user input selecting a first morphological analysis at the morphological analysis selection component, overlaying, on the first image of the biological tissue, a representation of a first result of the selected first morphological analysis, the first result of the first morphological analysis indicating one or more morphological features of interest in the first image, wherein the first image of the biological tissue and the representation of the first result are displayed in a visually distinguishable manner; and rendering, on the graphical user interface, a quality review selection component allowing the user to select a quality review score based on a comparison between the first image and the representation of the first result of the first morphological analysis rendered on the graphical user interface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A computer system for performing quality review of analysis of biological tissue, the system comprising:
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a visual display device; a data storage device for storing a data set comprising tissue profile data including multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue; and a computer processor coupled to the visual display device and the data storage device, the computer processor programmed to; render a graphical user interface on the visual display device, render, on the graphical user interface, a field of view selection component allowing a user to select a field of view from the data set stored on the data storage device, the field of view selection component allowing the user to configure a color and/or a transparency of a representation on the graphical user interface of biological tissue corresponding to a selected field of view, in response to user input selecting a field of view corresponding to a biological tissue at the field of view selection component, render, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue, render, on the graphical user interface, a morphological analysis selection component allowing a user to select a morphological analysis of multiplexed biomarker image data corresponding to the selected field of view, the morphological analysis selection component allowing the user to configure a color and/or a transparency of a representation of a result of a selected morphological analysis, in response to user input selecting a first morphological analysis at the morphological analysis selection component, overlay, on the first image of the biological tissue, a representation of a first result of the selected first morphological analysis, the first result of the first morphological analysis indicating one or more morphological features of interest in the first image, wherein the first image of the biological tissue and the representation of the first result are displayed in a visually distinguishable manner, and render, on the graphical user interface, a quality review selection component allowing the user to select a quality review score based on a comparison between the first image and the representation of the first result of the first morphological analysis rendered on the graphical user interface.
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Specification