Method and apparatus for stain separation using vector analysis
First Claim
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1. A computer-implemented method for stain separation of a pathology image using stain vector analysis comprising:
- converting an original image into an optical domain image;
performing stain vector analysis on the optical domain image to obtain one or more stain vectors;
deconvoluting the one or more stain vectors to produce one or more separated stain images;
isolating stain amounts in each color channel of the one or more separated stain images;
comparing, for each pixel in the original image, a pixel value from one of the one or more stain images to a pixel value in another image of the one or more stain images; and
selecting, for each pixel in the original image, a pixel value with a largest stain value, wherein a plurality of selected pixel values forms a strongest stain image.
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Abstract
A computer-implemented method and apparatus for stain separation of a pathology image using stain vector analysis comprising converting an original image into an optical domain image, performing stain vector analysis on the optical domain image to obtain one or more stain vectors, deconvoluting the vectors adaptively to produce one or more separated stain images.
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20 Claims
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1. A computer-implemented method for stain separation of a pathology image using stain vector analysis comprising:
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converting an original image into an optical domain image; performing stain vector analysis on the optical domain image to obtain one or more stain vectors; deconvoluting the one or more stain vectors to produce one or more separated stain images; isolating stain amounts in each color channel of the one or more separated stain images; comparing, for each pixel in the original image, a pixel value from one of the one or more stain images to a pixel value in another image of the one or more stain images; and selecting, for each pixel in the original image, a pixel value with a largest stain value, wherein a plurality of selected pixel values forms a strongest stain image. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An apparatus for stain separation of a pathology image using stain vector analysis, the apparatus comprising a processor that executes:
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a transform module that converts an original image into an optical domain image; a vector module, coupled to the transform module, that performs stain vector analysis on the optical domain image to obtain one or more stain vectors; a deconvolution module, coupled to the vector module, that deconvolutes the one or more vectors to produce one or more separated stain images; and an adaptive separation module that isolates stain amounts in each color channel of the one or more separated stain images and for each pixel in the original image, compares, for each pixel in the original image, a pixel value from one of the one or more stain images to a pixel value in another of the one or more stain images; and selects a pixel value from one of the one or more stain images with a largest stain value, wherein a plurality of selected pixel values form a strongest stain image. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification